Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D08CAB
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| Former ID |
DIB019698
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| Drug Name |
D-aspartic acid
|
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| Synonyms |
D-aspartate
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| Drug Type |
Small molecular drug
|
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| Indication | Discovery agent | Investigative | [541648] | ||
| Structure |
|
Download2D MOL |
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| Formula |
C4H7NO4
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| InChI |
InChI=1S/C4H7NO4/c5-2(4(8)9)1-3(6)7/h2H,1,5H2,(H,6,7)(H,8,9)/t2-/m1/s1
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| InChIKey |
CKLJMWTZIZZHCS-UWTATZPHSA-N
|
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| PubChem Compound ID | |||||
| PubChem Substance ID |
3692, 589764, 7886902, 7887197, 8144616, 10220391, 10511076, 11110794, 11113408, 11538062, 15219005, 15297263, 24853106, 26751646, 26751647, 29203865, 44415541, 46504502, 47731299, 47805597, 48029710, 48105253, 49746798, 49831413, 49872021, 57333713, 57581090, 76520148, 85163775, 85165078, 87562145, 90443754, 92298037, 99224355, 102851505, 103199585, 103824708, 104384438, 117544648, 117686986, 124886902, 126525716, 126595472, 126604317, 126609112, 126616645, 126650135, 127638311, 135048939, 135693961
|
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| Target and Pathway | |||||
| Target(s) | Glutamate [NMDA] receptor subunit epsilon 2 | Target Info | Agonist | [543838] | |
| Glutamate [NMDA] receptor subunit epsilon 1 | Target Info | Agonist | [543837] | ||
| GluN2C | Target Info | Agonist | [543839] | ||
| GluN2D | Target Info | Agonist | [543840] | ||
| NMDA receptor subunit NR1 | Target Info | Agonist | [543836] | ||
| KEGG Pathway | Ras signaling pathway | ||||
| Rap1 signaling pathway | |||||
| cAMP signaling pathway | |||||
| Neuroactive ligand-receptor interaction | |||||
| Circadian entrainment | |||||
| Long-term potentiation | |||||
| Glutamatergic synapse | |||||
| Dopaminergic synapse | |||||
| Alzheimer's disease | |||||
| Amyotrophic lateral sclerosis (ALS) | |||||
| Huntington's disease | |||||
| Cocaine addiction | |||||
| Amphetamine addiction | |||||
| Nicotine addiction | |||||
| Alcoholism | |||||
| Systemic lupus erythematosushsa04014:Ras signaling pathway | |||||
| Calcium signaling pathway | |||||
| PANTHER Pathway | Huntington disease | ||||
| Ionotropic glutamate receptor pathway | |||||
| Metabotropic glutamate receptor group III pathway | |||||
| Metabotropic glutamate receptor group I pathway | |||||
| Muscarinic acetylcholine receptor 1 and 3 signaling pathwayP00029:Huntington disease | |||||
| Muscarinic acetylcholine receptor 1 and 3 signaling pathway | |||||
| Pathway Interaction Database | ErbB4 signaling events | ||||
| Reelin signaling pathwayreelinpathway:Reelin signaling pathway | |||||
| Reactome | EPHB-mediated forward signaling | ||||
| Unblocking of NMDA receptor, glutamate binding and activation | |||||
| CREB phosphorylation through the activation of CaMKII | |||||
| Ras activation uopn Ca2+ infux through NMDA receptor | |||||
| RAF/MAP kinase cascadeR-HSA-438066:Unblocking of NMDA receptor, glutamate binding and activation | |||||
| RAF/MAP kinase cascadeR-HSA-3928662:EPHB-mediated forward signaling | |||||
| RAF/MAP kinase cascade | |||||
| WikiPathways | Hypothetical Network for Drug Addiction | ||||
| Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell | |||||
| BDNF signaling pathwayWP666:Hypothetical Network for Drug Addiction | |||||
| Alzheimers DiseaseWP706:SIDS Susceptibility Pathways | |||||
| Spinal Cord Injury | |||||
| BDNF signaling pathway | |||||
| Alzheimers Disease | |||||
| References | |||||
| Ref 543836 | (http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 455). | ||||
| Ref 543837 | (http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 456). | ||||
| Ref 543838 | (http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 457). | ||||
| Ref 543839 | (http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 458). | ||||
| Ref 543840 | (http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 459). | ||||
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