Drug Information

Drug General Information
Drug ID
D08CIE
Former ID
DNC001194
Drug Name
Raclopride
Drug Type
Small molecular drug
Indication Psychotic disorders [ICD9: 290-299; ICD10:F20-F29] Phase 4 [524579], [543312]
Structure
Download
2D MOL

3D MOL
Formula
C15H20Cl2N2O3
InChI
InChI=1S/C15H20Cl2N2O3/c1-3-19-6-4-5-9(19)8-18-15(21)12-13(20)10(16)7-11(17)14(12)22-2/h7,9,20H,3-6,8H2,1-2H3,(H,18,21)/t9-/m0/s1
InChIKey
WAOQONBSWFLFPE-VIFPVBQESA-N
CAS Number
CAS 84225-95-6
PubChem Compound ID
3033769
PubChem Substance ID
7980481, 10047782, 11114224, 12013470, 14827538, 26719717, 26752250, 36077621, 46386981, 47515551, 47810996, 48185204, 49681662, 50104962, 53787975, 57352765, 77953791, 85788759, 90340860, 91746408, 92308273, 92308736, 103167993, 103918664, 111634979, 124658776, 124800057, 124887054, 129553949, 134338685, 134340417, 135014074, 135650880, 135698402, 137237422, 142971008, 144204512, 152106370, 160821969, 162023238, 163091727, 163383825, 170466218, 170485724, 172080125, 172860716, 176484026, 178100336, 179151282, 198978423
Target and Pathway
Target(s) D(2) dopamine receptor Target Info Antagonist [537994]
KEGG Pathway Rap1 signaling pathway
cAMP signaling pathway
Neuroactive ligand-receptor interaction
Gap junction
Dopaminergic synapse
Parkinson's disease
Cocaine addiction
Alcoholism
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
Dopamine receptor mediated signaling pathway
Nicotine pharmacodynamics pathway
Reactome Dopamine receptors
G alpha (i) signalling events
WikiPathways Hypothetical Network for Drug Addiction
Monoamine GPCRs
GPCRs, Class A Rhodopsin-like
Genes and (Common) Pathways Underlying Drug Addiction
GPCR ligand binding
GPCR downstream signaling
Nicotine Activity on Dopaminergic Neurons
References
Ref 524579ClinicalTrials.gov (NCT02020408) Monoamine Contributions to Neurocircuitry in Eating Disorders. U.S. National Institutes of Health.
Ref 543312(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 94).
Ref 537994The effects of antipsychotic drugs on Fos protein expression in the prefrontal cortex: cellular localization and pharmacological characterization. Neuroscience. 1996 Jan;70(2):377-89.

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