Drug General Information
Drug ID
D08DOE
Former ID
DIB014004
Drug Name
ML-04
Synonyms
BTL-cg; HP-4; ML-04A; Urological therapeutics, Milkhaus; Human chorionic gonadotropin (benign prostate hyperplasia/prostatitis/cancer), Beech Tree Labs
Indication Myelodysplastic syndrome [ICD9: 238.7; ICD10:D46] Phase 2 [521530]
Company
Milkhaus Laboratory Inc
Structure
Download
2D MOL

3D MOL

Canonical SMILES
C(C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)<br />NCC(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)NC(C(=O)NCC(<br />=O)NCC(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)NC(C(=O)N<br />[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)NC(C(=O)N[C@H](C(=O)<br />N[C@H](C(=O)O)C(C)C)CCCNC(=N)N)[C@H](O)C)CS)CS)Cc1ccc(c<br />c1)O)[C@H](O)C)Cc1ccccc1)CO)C(C)C)[C@H](CC)C)CC(C)C)CS)<br />CC(=O)N)C(C)C)CCCNC(=N)N)CC(C)C)CCC(=O)O)(NC(=O)[C@@H](<br />NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(<br />=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)<br />[C@@H](NC(=O)[C@@H](N)C(C)C)CS)CO)CS)CCCNC(=N)N)CC(C)C)<br />C(C)C)Cc1ccccc1)CS)CCCNC(=N)N)CCCNC(=N)N)[C@H](O)C
CAS Number
CAS 116977-48-1
Target and Pathway
Target(s) Lutropin-choriogonadotropic hormone receptor Target Info Modulator [528609]
KEGG Pathway Calcium signaling pathway
Neuroactive ligand-receptor interaction
Ovarian steroidogenesis
Prolactin signaling pathway
NetPath Pathway FSH Signaling Pathway
Pathway Interaction Database Arf6 signaling events
PathWhiz Pathway Intracellular Signalling Through LHCGR Receptor and Luteinizing Hormone/Choriogonadotropin
Reactome Hormone ligand-binding receptors
G alpha (s) signalling events
WikiPathways GPCRs, Class A Rhodopsin-like
Ovarian Infertility Genes
Peptide GPCRs
GPCR ligand binding
GPCR downstream signaling
References
Ref 521530ClinicalTrials.gov (NCT00044226) A 20-Week Study of a New Treatment for Men With Benign Prostatic Hyperplasia (BPH).. U.S. National Institutes of Health.
Ref 528609Evaluation of radiolabeled ML04, a putative irreversible inhibitor of epidermal growth factor receptor, as a bioprobe for PET imaging of EGFR-overexpressing tumors. Nucl Med Biol. 2007 Jan;34(1):55-70.

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