Drug Information

Drug General Information
Drug ID
D08EMG
Former ID
DNC012717
Drug Name
(S)APOMORPHINE
Drug Type
Small molecular drug
Indication Discovery agent Investigative [543039]
Structure
Download
2D MOL

3D MOL
Formula
C17H17NO2
InChI
InChI=1S/C17H17NO2/c1-18-8-7-10-3-2-4-12-15(10)13(18)9-11-5-6-14(19)17(20)16(11)12/h2-6,13,19-20H,7-9H2,1H3/t13-/m0/s1
InChIKey
VMWNQDUVQKEIOC-ZDUSSCGKSA-N
PubChem Compound ID
736083
PubChem Substance ID
11110737, 24671926, 26088392, 26754246, 35412028, 47252419, 47550611, 47623931, 50322704, 57408699, 57736768, 90451435, 103236763, 103923437, 108667036, 109885511, 126651798, 129497606, 131289772, 134349922, 135266545, 135609359, 138621171, 162517257, 179235808, 225157380, 232597267, 252166497, 252614855
Target and Pathway
Target(s) Dopamine D1 receptor Target Info Inhibitor [530342]
D(2) dopamine receptor Target Info Inhibitor [530342]
KEGG Pathway Calcium signaling pathway
cAMP signaling pathway
Neuroactive ligand-receptor interaction
Gap junction
Dopaminergic synapse
Parkinson's disease
Cocaine addiction
Amphetamine addiction
Morphine addiction
Alcoholismhsa04015:Rap1 signaling pathway
Alcoholism
PANTHER Pathway Dopamine receptor mediated signaling pathwayP00026:Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
Dopamine receptor mediated signaling pathway
Nicotine pharmacodynamics pathway
PathWhiz Pathway Dopamine Activation of Neurological Reward System
Reactome Dopamine receptors
G alpha (s) signalling eventsR-HSA-390651:Dopamine receptors
G alpha (i) signalling events
WikiPathways Hypothetical Network for Drug Addiction
Monoamine GPCRs
GPCRs, Class A Rhodopsin-like
Genes and (Common) Pathways Underlying Drug Addiction
GPCR ligand binding
GPCR downstream signalingWP666:Hypothetical Network for Drug Addiction
GPCR downstream signaling
Nicotine Activity on Dopaminergic Neurons
References
Ref 543039(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 8285).
Ref 530342J Med Chem. 1990 Jun;33(6):1800-5.Synthesis and dopamine receptor affinities of enantiomers of 2-substituted apomorphines and their N-n-propyl analogues.

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