Drug General Information
Drug ID	D08EVM
Former ID	DIB001034
Drug Name	FR-128998
Indication	Thrombocytopenia [ICD9: 287.3, 287.4, 287.5; ICD10:D69.6, P61.0]		Terminated	[545711]
Company	Fujisawa Pharmaceutical Co Ltd
Structure		Download 2D MOL 3D MOL
Canonical SMILES	S1(=O)(=O)[C@@]2(CC(=O)N(CC1)Cc1cnccc1)[C@H](Cc1ccccc1)<br />CCCC2.Cl
CAS Number	CAS 133321-57-0
Target and Pathway
Target(s)	Platelet-activating factor receptor	Target Info	Modulator	[533881]
KEGG Pathway	Calcium signaling pathway
	Neuroactive ligand-receptor interaction
	Staphylococcus aureus infection
NetPath Pathway	IL5 Signaling Pathway
	Leptin Signaling Pathway
Reactome	Class A/1 (Rhodopsin-like receptors)
	G alpha (q) signalling events
	Interferon gamma signaling
WikiPathways	GPCRs, Class A Rhodopsin-like
	Gastrin-CREB signalling pathway via PKC and MAPK
	Small Ligand GPCRs
	Interferon gamma signaling
	GPCR ligand binding
	GPCR downstream signaling
References
Ref 545711	Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800004313)
Ref 533881	Effect of FR128998, a novel PAF receptor antagonist, on endotoxin-induced disseminated intravascular coagulation. Eur J Pharmacol. 1994 Jun 13;258(3):239-46.

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