TTD | Drug: D08EXR

Drug General Information
Drug ID	D08EXR
Former ID	DIB018964
Drug Name	beta-ergocriptine
Drug Type	Small molecular drug
Indication	Discovery agent		Investigative	[543349]
Structure		Download 2D MOL
Formula	C32H41N5O5
InChI	InChI=1S/C32H41N5O5/c1-6-18(4)27-29(39)36-12-8-11-25(36)32(41)37(27)30(40)31(42-32,17(2)3)34-28(38)20-13-22-21-9-7-10-23-26(21)19(15-33-23)14-24(22)35(5)16-20/h7,9-10,13,15,17-18,20,24-25,27,33,41H,6,8,11-12,14,16H2,1-5H3,(H,34,38)/t18-,20+,24+,25-,27+,31+,32-/m0/s1
InChIKey	YYWXOXLDOMRDHW-SGVWFJRMSA-N
PubChem Compound ID	161309
PubChem Substance ID	46236176, 48407596, 49965343, 57349469, 80439116, 103066998, 103066999, 103083542, 103083543, 113446738, 135117523, 135649985
Target and Pathway
Target(s)	D(1B) dopamine receptor	Target Info	Agonist	[529311]
KEGG Pathway	Calcium signaling pathway
	cAMP signaling pathway
	Neuroactive ligand-receptor interaction
	Dopaminergic synapse
PANTHER Pathway	Dopamine receptor mediated signaling pathway
Reactome	Dopamine receptors
Reactome	G alpha (s) signalling events
WikiPathways	Monoamine GPCRs
	GPCRs, Class A Rhodopsin-like
	GPCR ligand binding
	GPCR downstream signaling
References
Ref 543349	(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 988).
Ref 529311	Cloning of the gene for a human dopamine D5 receptor with higher affinity for dopamine than D1. Nature. 1991 Apr 18;350(6319):614-9.

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Drug Information