Drug Information

Drug General Information
Drug ID
D08FGX
Former ID
DNC010935
Drug Name
PALOSURAN
Drug Type
Small molecular drug
Indication Renal failure [ICD9: 584, 585; ICD10:N17, N18, N19] Discontinued in Phase 2 [540453], [547241]
Structure
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2D MOL

3D MOL
Formula
C25H30N4O2
InChI
InChI=1S/C25H30N4O2/c1-19-17-23(21-9-5-6-10-22(21)27-19)28-24(30)26-13-16-29-14-11-25(31,12-15-29)18-20-7-3-2-4-8-20/h2-10,17,31H,11-16,18H2,1H3,(H2,26,27,28,30)
InChIKey
WYJCYXOCHXWTHG-UHFFFAOYSA-N
PubChem Compound ID
10173280
PubChem Substance ID
15167346, 22569598, 40157429, 74670445, 103708450, 104156633, 135252606, 137263861, 141569399, 163783404, 178100499, 198951279, 210274718, 210280352, 223928749, 227581897, 246861756
Target and Pathway
Target(s) Urotensin II receptor Target Info Inhibitor [530610]
KEGG Pathway Neuroactive ligand-receptor interaction
Reactome Peptide ligand-binding receptors
G alpha (q) signalling events
WikiPathways Gastrin-CREB signalling pathway via PKC and MAPK
GPCR ligand binding
GPCR downstream signaling
GPCRs, Other
References
Ref 540453(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 3516).
Ref 547241Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800014355)
Ref 530610J Med Chem. 2010 Apr 8;53(7):2695-708.Urotensin-II receptor modulators as potential drugs.

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