Drug Information

Drug General Information
Drug ID
D08FRG
Former ID
DIB005859
Drug Name
EphA2-targeting BiTE molecules
Synonyms
BscEphA2xCD3; MEDI-544; Anticancer BiTE, Micromet/MedImmune; EphA2-targeting BiTE molecules, Micromet; Bispecific T-cell engager (cancer), MedImmune/Micromet
Indication Cancer [ICD9: 140-229; ICD10:C00-C96] Investigative [543506]
Company
Micromet AG
Target and Pathway
Target(s) Ephrin type-A receptor 2 Target Info Modulator [543506]
KEGG Pathway Ras signaling pathway
Rap1 signaling pathway
PI3K-Akt signaling pathway
Axon guidance
NetPath Pathway TGF_beta_Receptor Signaling Pathway
Pathway Interaction Database EphrinA-EPHA pathway
Arf6 signaling events
Direct p53 effectors
EPHA forward signaling
Stabilization and expansion of the E-cadherin adherens junction
EPHA2 forward signaling
Reactome EPH-Ephrin signaling
EPHA-mediated growth cone collapse
EPH-ephrin mediated repulsion of cells
WikiPathways NRF2 pathway
References
Ref 543506(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1822).
Ref 543506(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1822).

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