Drug General Information
Drug ID	D08FWK
Former ID	DIB005900
Drug Name	Oxypurinol
Synonyms	Oxypurinol (intravenous)
Drug Type	Small molecular drug
Indication	Heart failure [ICD9: 428; ICD10:I50]		Phase 2/3	[521563]
Company	Johns Hopkins University
Structure		Download 2D MOL 3D MOL
Formula	C5H4N4O2
Canonical SMILES	O=C1NC(=O)c2c[nH]nc2N1
InChI	1S/C5H4N4O2/c10-4-2-1-6-9-3(2)7-5(11)8-4/h1H,(H3,6,7,8,9,10,11)
InChIKey	HXNFUBHNUDHIGC-UHFFFAOYSA-N
PubChem Compound ID	4644
Target and Pathway
Target(s)	Xanthine dehydrogenase/oxidase	Target Info	Inhibitor	[533356]
BioCyc Pathway	Purine nucleotides degradation
	Urate biosynthesis/inosine 5'-phosphate degradation
	Guanosine nucleotides degradation
	Adenosine nucleotides degradation
	Retinoate biosynthesis II
KEGG Pathway	Purine metabolism
	Caffeine metabolism
	Drug metabolism - other enzymes
	Metabolic pathways
	Peroxisome
PANTHER Pathway	Adenine and hypoxanthine salvage pathway
	Purine metabolism
PathWhiz Pathway	Caffeine Metabolism
	Purine Metabolism
Reactome	Purine catabolism
WikiPathways	Oxidative Stress
	Effects of Nitric Oxide
	Metabolism of nucleotides
	Selenium Micronutrient Network
References
Ref 521563	ClinicalTrials.gov (NCT00063687) Oxypurinol Compared With Placebo for Class III-IV NYHA Congestive Heart Failure. U.S. National Institutes of Health.
Ref 533356	Oxypurinol as an inhibitor of xanthine oxidase-catalyzed production of superoxide radical. Biochem Pharmacol. 1988 Jan 15;37(2):349-52.

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