Drug Information

Drug General Information
Drug ID
D08HGY
Former ID
DIB005659
Drug Name
Naronapride
Synonyms
Naronapride dihydrochloride; ATI-7500; ATI-7505; Cisapride analog, ARYx Therapeutics; ATI-7000 series, ARYx Therapeutics; Cisapride analog, Procter & Gamble; ATI-7000 series, Procter & Gamble; 5-HT 4 receptor agonist (oral, gastroesophageal reflux/irritable bowel syndrome/gastric motilitydisorder/constipation/dyspepsia), ARYx Therapeutics/Procter & Gamble Pharmaceuticals Inc
Drug Type
Small molecular drug
Indication Gastroesophageal reflux disease [ICD9: 140-229, 530; ICD10:K21] Discontinued in Phase 2 [547851]
Company
ARYx Therapeutics
Structure
Download
2D MOL

3D MOL
Formula
C27H41ClN4O5
Canonical SMILES
c1(cc(c(cc1Cl)C(=O)N[C@H]1[C@H](CN(CC1)CCCCCC(=O)O[C@H]<br />1CN2CC[C@@H]1CC2)OC)OC)N
CAS Number
CAS 860174-12-5
PubChem Compound ID
11237985
Target and Pathway
Target(s) 5-hydroxytryptamine 4 receptor Target Info Agonist [531812]
KEGG Pathway Calcium signaling pathway
cAMP signaling pathway
Neuroactive ligand-receptor interaction
Serotonergic synapse
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
5HT4 type receptor mediated signaling pathway
PathWhiz Pathway Excitatory Neural Signalling Through 5-HTR 4 and Serotonin
Reactome Serotonin receptors
G alpha (s) signalling events
WikiPathways Serotonin Receptor 4/6/7 and NR3C Signaling
Monoamine GPCRs
GPCRs, Class A Rhodopsin-like
GPCR ligand binding
GPCR downstream signaling
References
Ref 547851Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800019926)
Ref 531812Systematic review: cardiovascular safety profile of 5-HT(4) agonists developed for gastrointestinal disorders. Aliment Pharmacol Ther. 2012 Apr;35(7):745-67.

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