Drug Information

Drug General Information
Drug ID
D08HZL
Former ID
DAP001077
Drug Name
Trimeprazine
Synonyms
Alimemazina; Alimemazine; Alimemazinum; Alimezine; Isobutrazine; Methylpromazine; Oxomemazin; Repetin; Teralen; Trimeperazine; Trimeprazine Tartrat; Bayer 1219; Alimemazina [INN-Spanish]; Alimemazine (INN); Alimemazine [INN:BAN]; Alimemazinum [INN-Latin]; Dl-Trimeprazine; Nedeltran (TN); Oxomemazine [DCF:INN]; Panectyl (TN); Repeltin (TN); Temaril (TN); Therafene (TN); Theralen (TN); Theralene (TN); Trimeprazine (BAN); Vallergan (TN); Vanectyl (TN); Trimeprazine 5,5-dioxide; Trimeprazine hemi-(+)-tartrate; N,N,beta-Trimethyl-10H-phenothiazine-10-propanamine; N,N,2-trimethyl-3-phenothiazin-10-ylpropan-1-amine; N,N,2-trimethyl-3-(10H-phenothiazin-10-yl)propan-1-amine; (+-)-Alimemazine; (+-)-Trimeprazine; 10-(2-Methyl-3-dimethylaminopropyl)-phenothiazine; 10-(3-(Dimethylamino)-2-methylpropyl)phenothiazine; 10-(3-Dimethylamino-2-methylpropyl)phenothiazine
Drug Type
Small molecular drug
Indication Allergic rhinitis [ICD9: 472.0, 477, 995.3; ICD10:J00, J30, J31.0, T78.4] Approved [542253], [550775]
Therapeutic Class
Antihistamines
Company
Allergan Herbert Skin Care Div Allergan Inc
Structure
Download
2D MOL

3D MOL
Formula
C18H22N2S
InChI
InChI=1S/C18H22N2S/c1-14(12-19(2)3)13-20-15-8-4-6-10-17(15)21-18-11-7-5-9-16(18)20/h4-11,14H,12-13H2,1-3H3
InChIKey
ZZHLYYDVIOPZBE-UHFFFAOYSA-N
CAS Number
CAS 84-96-8
PubChem Compound ID
5574
PubChem Substance ID
9381, 5664294, 7980834, 8153430, 10536926, 14998583, 26683957, 29224613, 46508449, 47662440, 48416667, 49698896, 50006469, 50543011, 51091464, 57244633, 57322852, 85209689, 92717845, 103216922, 103957784, 104309626, 125824456, 126621947, 126687442, 129976632, 134224850, 134338334, 134972661, 137120698, 141522740, 152102834, 160964578, 178103811, 179038167, 184534350, 198994073, 223441145, 223682819, 226408868, 241155290, 249924803
SuperDrug ATC ID
R06AD01
SuperDrug CAS ID
cas=000084968
Target and Pathway
Target(s) Histamine H1 receptor Target Info Antagonist [536153]
KEGG Pathway Calcium signaling pathway
Neuroactive ligand-receptor interaction
Inflammatory mediator regulation of TRP channels
PANTHER Pathway Histamine H1 receptor mediated signaling pathway
Reactome Histamine receptors
G alpha (q) signalling events
WikiPathways Monoamine GPCRs
GPCRs, Class A Rhodopsin-like
IL-4 Signaling Pathway
Gastrin-CREB signalling pathway via PKC and MAPK
GPCR ligand binding
GPCR downstream signaling
References
Ref 542253(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7237).
Ref 550775Drug information of Trimeprazine, 2008. eduDrugs.
Ref 536153Effectiveness of alimemazine in controlling retching after Nissen fundoplication. J Pediatr Surg. 2005 Nov;40(11):1737-40.

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