Drug General Information
Drug ID	D08KIB
Former ID	DIB012830
Drug Name	SAR-114137
Indication	Pain [ICD9: 338, 356.0, 356.8,780; ICD10:G64, G90.0, R52, G89]		Phase 1	[532135]
Company	Sanofi
Structure		Download 2D MOL 3D MOL
Target and Pathway
Target(s)	Cathepsin S	Target Info	Inhibitor	[532135]
	Cathepsin K	Target Info	Inhibitor	[532135]
KEGG Pathway	Lysosome
	Phagosome
	Antigen processing and presentation
	Tuberculosishsa04142:Lysosome
	Osteoclast differentiation
	Toll-like receptor signaling pathway
	Rheumatoid arthritis
NetPath Pathway	Leptin Signaling Pathway
	IL2 Signaling PathwayNetPath_7:TGF_beta_Receptor Signaling Pathway
	RANKL Signaling Pathway
	IL2 Signaling Pathway
Reactome	Endosomal/Vacuolar pathway
	Degradation of the extracellular matrix
	Trafficking and processing of endosomal TLR
	Assembly of collagen fibrils and other multimeric structures
	MHC class II antigen presentationR-HSA-1442490:Collagen degradation
	Activation of Matrix Metalloproteinases
	MHC class II antigen presentation
WikiPathways	Class I MHC mediated antigen processing & presentation
	Trafficking and processing of endosomal TLRWP2018:RANKL/RANK Signaling Pathway
	Osteoclast Signaling
References
Ref 532135	From laboratory to pilot plant: the solid-state process development of a highly potent cathepsin S/K inhibitor. Eur J Pharm Biopharm. 2013 Apr;83(3):436-48.
Ref 532135	From laboratory to pilot plant: the solid-state process development of a highly potent cathepsin S/K inhibitor. Eur J Pharm Biopharm. 2013 Apr;83(3):436-48.

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