Drug Information

Drug General Information
Drug ID
D08KLH
Former ID
DIB018402
Drug Name
[3H]RX821002
Synonyms
[3H]2-methoxyidazoxan
Drug Type
Small molecular drug
Indication Discovery agent Investigative [540743]
Structure
Download
2D MOL

3D MOL
Formula
C12H14N2O3
InChI
InChI=1S/C12H14N2O3/c1-15-12(11-13-6-7-14-11)8-16-9-4-2-3-5-10(9)17-12/h2-5H,6-8H2,1H3,(H,13,14)
InChIKey
HQGWKNGAKBPTBX-UHFFFAOYSA-N
PubChem Compound ID
108094
PubChem Substance ID
840954, 842020, 7536812, 7980550, 10234596, 11364712, 11367274, 11369836, 11378000, 11495622, 14749421, 44436992, 47572603, 48168573, 48393132, 49979496, 50104814, 57338437, 76822660, 85209706, 85788141, 90341601, 103169829, 103930440, 104380489, 124750201, 124881351, 128097672, 134224937, 134349649, 135066174, 135650954, 135651200, 136905176, 140884806, 141391967, 152253110, 162169298, 179236103, 228600997
Target and Pathway
Target(s) Alpha-2C adrenergic receptor Target Info Antagonist [533799]
Alpha-2B adrenergic receptor Target Info Antagonist [533799]
KEGG Pathway cGMP-PKG signaling pathway
Neuroactive ligand-receptor interactionhsa04022:cGMP-PKG signaling pathway
Neuroactive ligand-receptor interaction
PANTHER Pathway Alpha adrenergic receptor signaling pathway
Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathwayP00002:Alpha adrenergic receptor signaling pathway
Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
Reactome Adrenoceptors
Adrenaline signalling through Alpha-2 adrenergic receptor
Adrenaline,noradrenaline inhibits insulin secretion
G alpha (i) signalling events
G alpha (z) signalling events
Surfactant metabolismR-HSA-390696:Adrenoceptors
WikiPathways Monoamine GPCRs
GPCRs, Class A Rhodopsin-like
Platelet Aggregation (Plug Formation)
Integration of energy metabolism
GPCR ligand binding
GPCR downstream signalingWP58:Monoamine GPCRs
GPCR downstream signaling
References
Ref 540743(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 528).
Ref 533799Further characterization of human alpha 2-adrenoceptor subtypes: [3H]RX821002 binding and definition of additional selective drugs. Eur J Pharmacol. 1994 Jan 24;252(1):43-9.

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