Drug Information

Drug General Information
Drug ID
D08LUT
Former ID
DIB009783
Drug Name
ABT-702
Drug Type
Small molecular drug
Indication Pain [ICD9: 338, 356.0, 356.8,780; ICD10:G64, G90.0, R52, G89] Terminated [468195], [547299]
Company
Abbott Laboratories
Structure
Download
2D MOL

3D MOL
Formula
C22H19BrN6O
InChI
InChI=1S/C22H19BrN6O/c23-16-3-1-2-14(10-16)17-11-18(28-22-20(17)21(24)26-13-27-22)15-4-5-19(25-12-15)29-6-8-30-9-7-29/h1-5,10-13H,6-9H2,(H2,24,26,27,28)
InChIKey
RQCXKDWOCUJWQZ-UHFFFAOYSA-N
CAS Number
CAS 214697-26-4
PubChem Compound ID
1973
PubChem Substance ID
5199949, 7978844, 8151357, 14833946, 29221162, 48184801, 50034984, 80516739, 85789089, 90340633, 103256585, 103992579, 104299246, 124891594, 126407253, 129165659, 135328218, 139403775, 163221953, 178101823, 179148345, 198962337, 228078912, 252160895
Target and Pathway
Target(s) Adenosine kinase Target Info Inhibitor [532399]
BioCyc Pathway Superpathway of purine nucleotide salvage
Adenine and adenosine salvage II
KEGG Pathway Purine metabolism
Metabolic pathways
Reactome Purine salvage
WikiPathways Metabolism of nucleotides
References
Ref 468195(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 5131).
Ref 547299Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800014976)
Ref 532399ABT-702, an adenosine kinase inhibitor, attenuates inflammation in diabetic retinopathy. Life Sci. 2013 Jul 30;93(2-3):78-88.

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