Drug Information

Drug General Information
Drug ID
D08MEN
Former ID
DNC009419
Drug Name
KF-A5
Drug Type
Small molecular drug
Indication Discovery agent Investigative [529032]
Structure
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2D MOL

3D MOL
Formula
C22H28N2O
Canonical SMILES
CCN(CC)CCCCCN1C2=CC=CC=C2C(=O)C3=CC=CC=C31
InChI
1S/C22H28N2O/c1-3-23(4-2)16-10-5-11-17-24-20-14-8-6-12-18(20)22(25)19-13-7-9-15-21(19)24/h6-9,12-15H,3-5,10-11,16-17H2,1-2H3
InChIKey
YCWGZWYJTIJTHX-UHFFFAOYSA-N
PubChem Compound ID
14014889
Target and Pathway
Target(s) Sodium-dependent serotonin transporter Target Info Inhibitor [529032]
Sodium-dependent noradrenaline transporter Target Info Inhibitor [529032]
KEGG Pathway Serotonergic synapse
NetPath Pathway TCR Signaling Pathway
PANTHER Pathway 5HT1 type receptor mediated signaling pathway
5HT2 type receptor mediated signaling pathway
5HT3 type receptor mediated signaling pathway
5HT4 type receptor mediated signaling pathwayP00001:Adrenaline and noradrenaline biosynthesis
Reactome Na+/Cl- dependent neurotransmitter transporters
WikiPathways Monoamine Transport
SIDS Susceptibility Pathways
NRF2 pathway
Synaptic Vesicle Pathway
Serotonin Transporter ActivityWP727:Monoamine Transport
Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds
References
Ref 529032Antimicrob Agents Chemother. 2007 Nov;51(11):4133-40. Epub 2007 Sep 10.Design, synthesis, and evaluation of 10-N-substituted acridones as novel chemosensitizers in Plasmodium falciparum.
Ref 529032Antimicrob Agents Chemother. 2007 Nov;51(11):4133-40. Epub 2007 Sep 10.Design, synthesis, and evaluation of 10-N-substituted acridones as novel chemosensitizers in Plasmodium falciparum.

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