Drug General Information
Drug ID	D08MVY
Former ID	DIB009315
Drug Name	R-116712
Indication	Pain [ICD9: 338, 356.0, 356.8,780; ICD10:G64, G90.0, R52, G89]		Investigative	[525710]
Company	Janssen Pharmaceutica NV
Structure		Download 2D MOL 3D MOL
Canonical SMILES	c1(c2c(c(c(c1)Cl)N)OCCO2)C(=O)OC[C@@H]1[C@H](CN(CC1)CCC<br />C)O
CAS Number	CAS 195627-15-7
Target and Pathway
Target(s)	5-hydroxytryptamine 4 receptor	Target Info	Antagonist	[525710]
KEGG Pathway	Calcium signaling pathway
	cAMP signaling pathway
	Neuroactive ligand-receptor interaction
	Serotonergic synapse
PANTHER Pathway	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
	5HT4 type receptor mediated signaling pathway
PathWhiz Pathway	Excitatory Neural Signalling Through 5-HTR 4 and Serotonin
Reactome	Serotonin receptors
	G alpha (s) signalling events
WikiPathways	Serotonin Receptor 4/6/7 and NR3C Signaling
	Monoamine GPCRs
	GPCRs, Class A Rhodopsin-like
	GPCR ligand binding
	GPCR downstream signaling
References
Ref 525710	Mapping of serotonin 5-HT(4) receptor mRNA and ligand binding sites in the post-mortem human brain. Synapse. 2000 Apr;36(1):35-46.
Ref 525710	Mapping of serotonin 5-HT(4) receptor mRNA and ligand binding sites in the post-mortem human brain. Synapse. 2000 Apr;36(1):35-46.

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