Drug Information

Drug General Information
Drug ID
D08PBB
Former ID
DNC000854
Drug Name
L-694,458
Drug Type
Small molecular drug
Indication Cystic fibrosis [ICD9: 277; ICD10:E84] Phase 2 [551850]
Structure
Download
2D MOL

3D MOL
Formula
C31H40N4O6
Canonical SMILES
CCCC(C1=CC2=C(C=C1)OCO2)NC(=O)N3C(C(C3=O)(CC)CC)OC4=CC=<br />C(C=C4)C(=O)N5CCN(CC5)C
InChI
1S/C31H40N4O6/c1-5-8-24(22-11-14-25-26(19-22)40-20-39-25)32-30(38)35-28(37)31(6-2,7-3)29(35)41-23-12-9-21(10-13-23)27(36)34-17-15-33(4)16-18-34/h9-14,19,24,29H,5-8,15-18,20H2,1-4H3,(H,32,38)/t24-,29+/m1/s1
InChIKey
ZSDCIRYNTCVTMF-GIGWZHCTSA-N
CAS Number
CAS 157341-41-8
PubChem Compound ID
177992
PubChem Substance ID
10258824, 14812969, 14837631, 33501323, 76570568, 103284927, 103961532, 104426838, 126671449, 134339075, 134340163, 135154870, 142336332, 152258908, 160647754, 160832438, 162797666, 163397633, 163844255, 180100906, 184527598, 185972329, 189659308, 198958258, 204429446, 223660457, 232251389, 244216908, 251963056, 252504726
Target and Pathway
Target(s) Leukocyte elastase Target Info Inhibitor [535494]
KEGG Pathway Transcriptional misregulation in cancer
Systemic lupus erythematosus
Pathway Interaction Database Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling
C-MYB transcription factor network
Reactome Collagen degradation
Degradation of the extracellular matrix
Activation of Matrix Metalloproteinases
WikiPathways Hair Follicle Development: Cytodifferentiation (Part 3 of 3)
Human Complement System
Degradation of collagen
References
Ref 551850New Drugs and Targets for Asthma and COPD, T.T. Hansel, ??.J. Barnes. Page(248).
Ref 535494Neutrophil elastase inhibitors as treatment for COPD. Expert Opin Investig Drugs. 2002 Jul;11(7):965-80.

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