Drug Information

Drug General Information
Drug ID
D08PIK
Former ID
DIB005985
Drug Name
11C-GSK-215083
Synonyms
11C-5-HT 6 receptor antagonist (neurodegenerative disease), GlaxoSmithKline; 11C-GSK-215083 PET maging agent (neurodegenerative disease), GlaxoSmithKline
Indication Neurodegenerative disease [ICD9: 330-337; ICD10:G30-G32] Phase 1 [525385], [543132]
Company
GlaxoSmithKline plc
Structure
Download
2D MOL

3D MOL
InChI
InChI=1S/C20H20FN3O2S/c1-23-8-10-24(11-9-23)19-7-2-4-15-12-18(14-22-20(15)19)27(25,26)17-6-3-5-16(21)13-17/h2-7,12-14H,8-11H2,1H3/i1-1
InChIKey
PXVJEDOZGDZJQY-BJUDXGSMSA-N
Target and Pathway
Target(s) 5-hydroxytryptamine 6 receptor Target Info Antagonist [531758]
KEGG Pathway Calcium signaling pathway
cAMP signaling pathway
Neuroactive ligand-receptor interaction
Serotonergic synapse
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
PathWhiz Pathway Excitatory Neural Signalling Through 5-HTR 6 and Serotonin
Reactome Serotonin receptors
G alpha (s) signalling events
WikiPathways Serotonin Receptor 4/6/7 and NR3C Signaling
Monoamine GPCRs
GPCRs, Class A Rhodopsin-like
GPCR ligand binding
GPCR downstream signaling
References
Ref 525385List of drugs in development for neurodegenerative diseases: update October 2011. Neurodegener Dis. 2012;9(4):210-83.
Ref 543132(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 8430).
Ref 531758Radiosynthesis and characterization of 11C-GSK215083 as a PET radioligand for the 5-HT6 receptor. J Nucl Med. 2012 Feb;53(2):295-303.

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