Drug Information

Drug General Information
Drug ID
D08QBS
Former ID
DNC009883
Drug Name
MK-1925
Drug Type
Small molecular drug
Indication Discovery agent Investigative [530242]
Structure
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2D MOL

3D MOL
Formula
C19H21F3N4
Canonical SMILES
CC1=C(N(N=C1CNC2CCC(C2)F)CCC#N)C3=CC(=CC(=C3)F)F
InChI
1S/C19H21F3N4/c1-12-18(11-24-17-4-3-14(20)10-17)25-26(6-2-5-23)19(12)13-7-15(21)9-16(22)8-13/h7-9,14,17,24H,2-4,6,10-11H2,1H3
InChIKey
LJTOZIFFXNLWEQ-UHFFFAOYSA-N
PubChem Compound ID
44178080
Target and Pathway
Target(s) Kappa-type opioid receptor Target Info Inhibitor [530242]
Potassium voltage-gated channel subfamily H member 2 Target Info Inhibitor [530242]
KEGG Pathway Neuroactive ligand-receptor interaction
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
Opioid prodynorphin pathway
PathWhiz Pathway Muscle/Heart Contraction
Reactome Peptide ligand-binding receptors
G alpha (i) signalling eventsR-HSA-1296072:Voltage gated Potassium channels
WikiPathways GPCRs, Class A Rhodopsin-like
Peptide GPCRs
GPCR ligand binding
GPCR downstream signalingWP706:SIDS Susceptibility Pathways
Hematopoietic Stem Cell Differentiation
Potassium Channels
References
Ref 530242Bioorg Med Chem Lett. 2009 Aug 15;19(16):4729-32. Epub 2009 Jun 17.Identification of MK-1925: a selective, orally active and brain-penetrable opioid receptor-like 1 (ORL1) antagonist.
Ref 530242Bioorg Med Chem Lett. 2009 Aug 15;19(16):4729-32. Epub 2009 Jun 17.Identification of MK-1925: a selective, orally active and brain-penetrable opioid receptor-like 1 (ORL1) antagonist.

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