Drug General Information
Drug ID
D08RCH
Former ID
DNC009420
Drug Name
KF-A6
Drug Type
Small molecular drug
Indication Discovery agent Investigative [529032]
Structure
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2D MOL

3D MOL

Formula
C23H30N2O
Canonical SMILES
CCN(CC)CCCCCCN1C2=CC=CC=C2C(=O)C3=CC=CC=C31
InChI
1S/C23H30N2O/c1-3-24(4-2)17-11-5-6-12-18-25-21-15-9-7-13-19(21)23(26)20-14-8-10-16-22(20)25/h7-10,13-16H,3-6,11-12,17-18H2,1-2H3
InChIKey
YHXSELHUXJAOLR-UHFFFAOYSA-N
PubChem Compound ID
Target and Pathway
Target(s) Sodium-dependent serotonin transporter Target Info Inhibitor [529032]
Histamine H1 receptor Target Info Inhibitor [529032]
KEGG Pathway Serotonergic synapsehsa04020:Calcium signaling pathway
Neuroactive ligand-receptor interaction
Inflammatory mediator regulation of TRP channels
NetPath Pathway TCR Signaling Pathway
PANTHER Pathway 5HT1 type receptor mediated signaling pathway
5HT2 type receptor mediated signaling pathway
5HT3 type receptor mediated signaling pathway
5HT4 type receptor mediated signaling pathwayP04385:Histamine H1 receptor mediated signaling pathway
Reactome Histamine receptors
G alpha (q) signalling events
WikiPathways Monoamine Transport
SIDS Susceptibility Pathways
NRF2 pathway
Synaptic Vesicle Pathway
Serotonin Transporter ActivityWP58:Monoamine GPCRs
GPCRs, Class A Rhodopsin-like
IL-4 Signaling Pathway
Gastrin-CREB signalling pathway via PKC and MAPK
GPCR ligand binding
GPCR downstream signaling
References
Ref 529032Antimicrob Agents Chemother. 2007 Nov;51(11):4133-40. Epub 2007 Sep 10.Design, synthesis, and evaluation of 10-N-substituted acridones as novel chemosensitizers in Plasmodium falciparum.
Ref 529032Antimicrob Agents Chemother. 2007 Nov;51(11):4133-40. Epub 2007 Sep 10.Design, synthesis, and evaluation of 10-N-substituted acridones as novel chemosensitizers in Plasmodium falciparum.

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