Drug Information

Drug General Information
Drug ID
D08RZV
Former ID
DIB012931
Drug Name
HSR-609
Synonyms
FY-609; 3-[4-(8-Fluoro-5,11-dihydrobenz[b]oxepino[4,3-b]pyridin-11-ylidene)piperidin-1-yl]propionic acid dihydrate
Drug Type
Small molecular drug
Indication Rhinitis [ICD9: 472.0, 477; ICD10:J00, J30, J31.0] Discontinued in Phase 2 [545924]
Structure
Download
2D MOL

3D MOL
Formula
C21H25FN2O5
Canonical SMILES
C1CN(CCC1=C2C3=C(C=C(C=C3)F)OCC4=C2N=CC=C4)CCC(=O)O.O.O
InChI
1S/C21H21FN2O3.2H2O/c22-16-3-4-17-18(12-16)27-13-15-2-1-8-23-21(15)20(17)14-5-9-24(10-6-14)11-7-19(25)26;;/h1-4,8,12H,5-7,9-11,13H2,(H,25,26);2*1H2
InChIKey
CWNCDQYLHMXURI-UHFFFAOYSA-N
CAS Number
CAS 153250-51-2
PubChem Compound ID
3081352
PubChem Substance ID
9471111, 12014816, 36412163, 50584980, 57354673, 111682618, 135228214
Target and Pathway
Target(s) Histamine H1 receptor Target Info Antagonist [534391], [551871]
KEGG Pathway Calcium signaling pathway
Neuroactive ligand-receptor interaction
Inflammatory mediator regulation of TRP channels
PANTHER Pathway Histamine H1 receptor mediated signaling pathway
Reactome Histamine receptors
G alpha (q) signalling events
WikiPathways Monoamine GPCRs
GPCRs, Class A Rhodopsin-like
IL-4 Signaling Pathway
Gastrin-CREB signalling pathway via PKC and MAPK
GPCR ligand binding
GPCR downstream signaling
References
Ref 545924Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800005369)
Ref 534391Studies on the novel antiallergic agent HSR-609: its penetration into the central nervous system in mice and guinea pigs and its selectivity for the histamine H1-receptor. Jpn J Pharmacol. 1997 Apr;73(4):291-8.
Ref 551871Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015

If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.