Drug Information

Drug General Information
Drug ID
D08SEI
Former ID
DAP000335
Drug Name
Levocabastine
Synonyms
Levocabastin; Levocabastina; Levocabastinum; Livostin; Levocabastina [Spanish]; Levocabastinum [Latin]; Levocabastine (INN); Levocabastine [INN:BAN]; Livostin (TN); (3S,4R)-1-[4-cyano-4-(4-fluorophenyl)cyclohexyl]-3-methyl-4-phenylpiperidine-4-carboxylic acid; 1-(4-cyano-4-(4-fluorophenyl)cyclohexyl)-3-methyl-4-phenyl-4-piperidinecarboxylic acid
Drug Type
Small molecular drug
Indication Allergic conjunctivitis [ICD9: 204.0, 372.0, 372.14, 995.3; ICD10:C91.0, H10, H10.45, T78.4] Approved [536119], [538963]
Therapeutic Class
Antiallergic Agents
Company
Janssen Pharmaceutica
Structure
Download
2D MOL

3D MOL
Formula
C26H29FN2O2
InChI
InChI=1S/C26H29FN2O2/c1-19-17-29(16-15-26(19,24(30)31)21-5-3-2-4-6-21)23-11-13-25(18-28,14-12-23)20-7-9-22(27)10-8-20/h2-10,19,23H,11-17H2,1H3,(H,30,31)/t19-,23-,25-,26-/m1/s1
InChIKey
ZCGOMHNNNFPNMX-KYTRFIICSA-N
CAS Number
CAS 79516-68-0
PubChem Compound ID
54385
PubChem Substance ID
7979772, 11467067, 11468187, 11486844, 14807001, 15501039, 32961388, 34718386, 46505909, 47349573, 47573562, 47646743, 47795244, 49699381, 50065214, 50123948, 50473844, 57313613, 85788903, 96024807, 104304776, 124893604, 126666083, 134221875, 134337647, 135257219, 135650515, 136081779, 137005452, 137263743, 160964440, 163693550, 163852910, 175265815, 176484508, 179116755, 180191810, 194168802, 198974741, 223532782, 223681847, 226396552, 226517688, 242042090, 248745270
SuperDrug ATC ID
R01AC02; S01GX02
SuperDrug CAS ID
cas=079516680
Target and Pathway
Target(s) Histamine H1 receptor Target Info Antagonist [535848], [536800]
KEGG Pathway Calcium signaling pathway
Neuroactive ligand-receptor interaction
Inflammatory mediator regulation of TRP channels
PANTHER Pathway Histamine H1 receptor mediated signaling pathway
Reactome Histamine receptors
G alpha (q) signalling events
WikiPathways Monoamine GPCRs
GPCRs, Class A Rhodopsin-like
IL-4 Signaling Pathway
Gastrin-CREB signalling pathway via PKC and MAPK
GPCR ligand binding
GPCR downstream signaling
References
Ref 536119Emerging drugs for ocular allergy. Expert Opin Emerg Drugs. 2005 Aug;10(3):505-20.
Ref 538963(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 1586).
Ref 535848Effects of fexofenadine and other antihistamines on components of the allergic response: adhesion molecules. J Allergy Clin Immunol. 2003 Oct;112(4 Suppl):S78-82.
Ref 536800Contribution of alpha4beta1 integrin to the antiallergic effect of levocabastine. Biochem Pharmacol. 2008 Sep 15;76(6):751-62. Epub 2008 Jul 15.

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