Drug Information

Drug General Information
Drug ID
D08SMK
Former ID
DNC007866
Drug Name
2-(1-tosyl-1H-indol-3-yl)ethanamine
Drug Type
Small molecular drug
Indication Discovery agent Investigative [529112]
Structure
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2D MOL

3D MOL
Formula
C17H18N2O2S
Canonical SMILES
CC1=CC=C(C=C1)S(=O)(=O)N2C=C(C3=CC=CC=C32)CCN
InChI
1S/C17H18N2O2S/c1-13-6-8-15(9-7-13)22(20,21)19-12-14(10-11-18)16-4-2-3-5-17(16)19/h2-9,12H,10-11,18H2,1H3
InChIKey
XKKWGBDMWUAPLE-UHFFFAOYSA-N
PubChem Compound ID
14571158
Target and Pathway
Target(s) 5-hydroxytryptamine 6 receptor Target Info Inhibitor [529112]
KEGG Pathway Calcium signaling pathway
cAMP signaling pathway
Neuroactive ligand-receptor interaction
Serotonergic synapse
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
PathWhiz Pathway Excitatory Neural Signalling Through 5-HTR 6 and Serotonin
Reactome Serotonin receptors
G alpha (s) signalling events
WikiPathways Serotonin Receptor 4/6/7 and NR3C Signaling
Monoamine GPCRs
GPCRs, Class A Rhodopsin-like
GPCR ligand binding
GPCR downstream signaling
References
Ref 529112J Med Chem. 2007 Nov 15;50(23):5535-8. Epub 2007 Oct 19.Discovery of N1-(6-chloroimidazo[2,1-b][1,3]thiazole-5-sulfonyl)tryptamine as a potent, selective, and orally active 5-HT(6) receptor agonist.
Ref 529112J Med Chem. 2007 Nov 15;50(23):5535-8. Epub 2007 Oct 19.Discovery of N1-(6-chloroimidazo[2,1-b][1,3]thiazole-5-sulfonyl)tryptamine as a potent, selective, and orally active 5-HT(6) receptor agonist.

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