Drug General Information
Drug ID	D08SNX
Former ID	DIB013494
Drug Name	V-11294A
Synonyms	Rolipram derivatives, Napp
Indication	Asthma [ICD10:J45]		Discontinued in Phase 2	[547058]
Company	Napp Pharmaceutical Group Ltd
Structure		Download 2D MOL 3D MOL
Canonical SMILES	c12c(nc(n1)C(C)C)n(cnc2NCC)Cc1cc(OC2CCCC2)c(cc1)OC.Cl
CAS Number	CAS 162278-09-3
Target and Pathway
Target(s)	CAMP-specific 3',5'-cyclic phosphodiesterase 4B	Target Info	Inhibitor	[526464]
	Type IV phosphodiesterase	Target Info	Inhibitor	[526464]
	CAMP-specific 3',5'-cyclic phosphodiesterase 4A	Target Info	Inhibitor	[526464]
KEGG Pathway	Purine metabolism
	cAMP signaling pathway
	Morphine addictionhsa00230:Purine metabolism
	Morphine addiction
NetPath Pathway	IL5 Signaling Pathway
	IL2 Signaling Pathway
PathWhiz Pathway	Purine Metabolism
Reactome	DARPP-32 events
	G alpha (s) signalling eventsR-HSA-180024:DARPP-32 events
	G alpha (s) signalling events
WikiPathways	G Protein Signaling Pathways
	Myometrial Relaxation and Contraction Pathways
	Nuclear Receptors Meta-Pathway
	Opioid SignallingWP35:G Protein Signaling Pathways
	TSH signaling pathwayWP35:G Protein Signaling Pathways
References
Ref 547058	Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800012597)
Ref 526464	Pharmacokinetic and pharmacodynamic profile following oral administration of the phosphodiesterase (PDE)4 inhibitor V11294A in healthy volunteers. Br J Clin Pharmacol. 2002 Nov;54(5):478-84.

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