Drug General Information
Drug ID	D08TAN
Former ID	DIB018066
Drug Name	(+)-HA966
Synonyms	(R)-(+)-HA-966
Drug Type	Small molecular drug
Indication	Discovery agent		Investigative	[540660]
Structure		Download 2D MOL
Formula	C4H8N2O2
InChI	InChI=1S/C4H8N2O2/c5-3-1-2-6(8)4(3)7/h3,8H,1-2,5H2/t3-/m1/s1
InChIKey	HCKUBNLZMKAEIN-GSVOUGTGSA-N
PubChem Compound ID	6603720
PubChem Substance ID	11110801, 11113433, 11646357, 14747531, 24895449, 26751668, 43223520, 47659921, 48332001, 78937773, 91704375, 103365242, 103945602, 114636864, 128040680, 132556478, 137095810, 142354527, 162022525, 162226728, 178100889, 223554796, 228065563, 241181601, 252322020
Target and Pathway
Target(s)	Glutamate [NMDA] receptor subunit epsilon 2	Target Info	Agonist	[543838]
	NMDA receptor subunit NR1	Target Info	Agonist	[543836]
	Glutamate [NMDA] receptor subunit epsilon 1	Target Info	Agonist	[543837]
KEGG Pathway	Ras signaling pathway
	Rap1 signaling pathway
	cAMP signaling pathway
	Neuroactive ligand-receptor interaction
	Circadian entrainment
	Long-term potentiation
	Glutamatergic synapse
	Dopaminergic synapse
	Alzheimer's disease
	Amyotrophic lateral sclerosis (ALS)
	Huntington's disease
	Cocaine addiction
	Amphetamine addiction
	Nicotine addiction
	Alcoholism
	Systemic lupus erythematosushsa04014:Ras signaling pathway
	Calcium signaling pathway
	Alcoholismhsa04014:Ras signaling pathway
	Systemic lupus erythematosus
PANTHER Pathway	Huntington disease
	Ionotropic glutamate receptor pathway
	Metabotropic glutamate receptor group III pathway
	Metabotropic glutamate receptor group I pathway
	Muscarinic acetylcholine receptor 1 and 3 signaling pathwayP00029:Huntington disease
	Muscarinic acetylcholine receptor 1 and 3 signaling pathway
Pathway Interaction Database	ErbB4 signaling events
	Reelin signaling pathwayreelinpathway:Reelin signaling pathway
Reactome	EPHB-mediated forward signaling
	Unblocking of NMDA receptor, glutamate binding and activation
	CREB phosphorylation through the activation of CaMKII
	Ras activation uopn Ca2+ infux through NMDA receptor
	RAF/MAP kinase cascadeR-HSA-3928662:EPHB-mediated forward signaling
	RAF/MAP kinase cascadeR-HSA-438066:Unblocking of NMDA receptor, glutamate binding and activation
	RAF/MAP kinase cascade
WikiPathways	Hypothetical Network for Drug Addiction
	Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell
	BDNF signaling pathwayWP706:SIDS Susceptibility Pathways
	Spinal Cord Injury
	BDNF signaling pathway
	Alzheimers DiseaseWP666:Hypothetical Network for Drug Addiction
	Alzheimers Disease
References
Ref 540660	(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 4066).
Ref 543836	(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 455).
Ref 543837	(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 456).
Ref 543838	(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 457).

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