Drug Information

Drug General Information
Drug ID
D08TEJ
Former ID
DIB007590
Drug Name
CB-03-01
Synonyms
Cortexolone 17alpha-propionate; Androgen receptor antagonist (alopecia, acne, seborrhea, hirsuitism), Cosmo
Drug Type
Small molecular drug
Indication Acne vulgaris [ICD9: 706.1; ICD10:L70.0] Phase 2 [548553]
Company
Cosmo Pharmaceuticals SpA
Structure
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2D MOL

3D MOL
Formula
C24H34O5
Canonical SMILES
[C@]1([C@@]2([C@@H](CC1)[C@H]1[C@H](CC2)[C@@]2(C(=CC(=O<br />)CC2)CC1)C)C)(OC(=O)CC)C(=O)CO
PubChem Compound ID
11750009
Target and Pathway
Target(s) Androgen receptor Target Info Antagonist [527374]
KEGG Pathway Oocyte meiosis
Pathways in cancer
Prostate cancer
NetPath Pathway EGFR1 Signaling Pathway
AndrogenReceptor Signaling Pathway
FSH Signaling Pathway
Pathway Interaction Database Regulation of nuclear SMAD2/3 signaling
Coregulation of Androgen receptor activity
Regulation of Androgen receptor activity
Nongenotropic Androgen signaling
Regulation of nuclear beta catenin signaling and target gene transcription
FOXA1 transcription factor network
Notch-mediated HES/HEY network
Reactome Nuclear Receptor transcription pathway
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3
WikiPathways SIDS Susceptibility Pathways
Integrated Pancreatic Cancer Pathway
Prostate Cancer
Integrated Breast Cancer Pathway
Nuclear Receptors
Androgen receptor signaling pathway
References
Ref 548553Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800026561)
Ref 527374Biological profile of cortexolone 17alpha-propionate (CB-03-01), a new topical and peripherally selective androgen antagonist. Arzneimittelforschung. 2004;54(12):881-6.

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