Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D08TVU
|
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| Former ID |
DIB019556
|
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| Drug Name |
compound 5n
|
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| Drug Type |
Small molecular drug
|
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| Indication | Discovery agent | Investigative | [530930] | ||
| Structure |
|
Download2D MOL |
|||
| Formula |
C24H24ClF3N6
|
||||
| InChI |
InChI=1S/C24H24ClF3N6/c25-19-1-2-20(24(26,27)28)18(11-19)15-34-10-7-31-23-21(34)12-17(14-32-23)16-3-4-30-22(13-16)33-8-5-29-6-9-33/h1-4,11-14,29H,5-10,15H2,(H,31,32)
|
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| InChIKey |
AHZCYZMNFBGXAC-UHFFFAOYSA-N
|
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| PubChem Compound ID | |||||
| PubChem Substance ID | |||||
| Target and Pathway | |||||
| Target(s) | ALK tyrosine kinase receptor | Target Info | Inhibitor | [530930] | |
| doublecortin-like kinase 3 | Target Info | Inhibitor | [543535] | ||
| Mitogen-activated protein kinasekinase kinase 3 | Target Info | Inhibitor | [530930] | ||
| KEGG Pathway | Non-small cell lung cancer | ||||
| NetPath Pathway | TSH Signaling Pathway | ||||
| Pathway Interaction Database | p38 MAPK signaling pathway | ||||
| Regulation of p38-alpha and p38-beta | |||||
| IL1-mediated signaling events | |||||
| TNF receptor signaling pathway | |||||
| Reactome | Interleukin-1 signaling | ||||
| References | |||||
| Ref 530930 | Synthesis and structure-activity relationships of 1,2,3,4-tetrahydropyrido[2,3-b]pyrazines as potent and selective inhibitors of the anaplastic lymphoma kinase. Bioorg Med Chem. 2010 Jun 15;18(12):4351-62. | ||||
| Ref 543535 | (http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2007). | ||||
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