Drug Information

Drug General Information
Drug ID
D08UMH
Former ID
DAP000680
Drug Name
Methylphenobarbital
Synonyms
Enfenemal; Enphenemal; Enphenemalum; Mebaral; Meberal; Mebroin; Mephobarbital; Mephobarbitone; Mephytal; Methylphenobarbitalum; Methylphenobarbitone; Methylphenobarbitonum; Methylphenolbarbital; Metilfenobarbital; Metilfenobarbitale; Metylfenemal; Metyna; Morbusan; Phemetone; Phemiton; Phemitone; Phenmiton; Prominal; Prominaletten; Prominalum; Mephobarbital [JAN]; Methyl phenobarbitone; Methylphenylbarbituric acid; Metilfenobarbitale [DCIT]; Sanofi Brand of Mephobarbital; Sanofi Synthelabo Brand of Mephobarbital; Isonal (roussel); Mebaral (TN); Menta-Bal; Methyl-calminal; Methylphenobarbital (INN); Methylphenobarbitalum [INN-Latin]; Metilfenobarbital [INN-Spanish]; N-Ethylmethylphenylbarbituric acid; N-Methylethylphenylbarbituric acid; N-Methylphenobarbital; N-Methylphenolbarbitol; Mephobarbital (JAN/USP); N-Methyl-5-phenyl-5-ethylbarbital; 1-Methyl-5-ethyl-5-phenylbarbituric acid; 1-Methyl-5-phenyl-5-ethylbarbituric acid; 1-Methylphenobarbital; 5-Ethyl-1-methyl-5-phenyl-2,4,6(1H,3H,5H)-pyrimidinetrione; 5-Ethyl-1-methyl-5-phenylbarbituric acid; 5-Ethyl-5-phenyl-N-methyl-bartituric acid; 5-Ethyl-N-methyl-5-phenylbarbituric acid; 5-Phenyl-5-ethyl-3-methylbarbituric acid; 5-ethyl-1-methyl-5-phenyl-1,3-diazinane-2,4,6-trione; 5-ethyl-1-methyl-5-phenylpyrimidine-2,4,6(1H,3H,5H)-trione
Drug Type
Small molecular drug
Indication Anxiety disorder [ICD9: 300, 311; ICD10:F32, F40-F42] Approved [550692]
Therapeutic Class
Hypnotics and Sedatives
Company
Ovation Pharmaceuticals
Structure
Download
2D MOL

3D MOL
Formula
C13H14N2O3
Canonical SMILES
CCC1(C(=O)NC(=O)N(C1=O)C)C2=CC=CC=C2
InChI
1S/C13H14N2O3/c1-3-13(9-7-5-4-6-8-9)10(16)14-12(18)15(2)11(13)17/h4-8H,3H2,1-2H3,(H,14,16,18)
InChIKey
ALARQZQTBTVLJV-UHFFFAOYSA-N
CAS Number
CAS 115-38-8
PubChem Compound ID
8271
PubChem Substance ID
10031, 5093039, 7847765, 7979946, 8147151, 8155794, 10504537, 14749710, 29215275, 29215276, 29226981, 46505197, 47833442, 48416217, 49874379, 56459436, 57324893, 76802480, 81093033, 87691917, 88488011, 92714690, 103224015, 104317381, 106801875, 117837484, 125823035, 127422109, 128099894, 134337969, 134974876, 137101290, 137240130, 144205153, 160964190, 164761780, 169763687, 177513116, 179226247, 181851673, 184548424, 226421831, 250086055, 252452819
ChEBI ID
ChEBI:6758
SuperDrug ATC ID
N03AA01
SuperDrug CAS ID
cas=000115388
Target and Pathway
Target(s) Gamma-aminobutyric acid receptor subunit alpha-1 Target Info Antagonist [536555], [537688]
KEGG Pathway Neuroactive ligand-receptor interaction
Retrograde endocannabinoid signaling
GABAergic synapse
Morphine addiction
Nicotine addiction
Reactome Ligand-gated ion channel transport
GABA A receptor activation
WikiPathways SIDS Susceptibility Pathways
Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell
Iron uptake and transport
References
Ref 550692Drug information of Methylphenobarbital, 2008. eduDrugs.
Ref 536555DrugBank: a knowledgebase for drugs, drug actions and drug targets. Nucleic Acids Res. 2008 Jan;36(Database issue):D901-6. Epub 2007 Nov 29.
Ref 537688Effect of barbiturates on polyphosphoinositide biosynthesis and protein kinase C activity in synaptosomes. Neuropharmacology. 1989 Dec;28(12):1317-23.

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