Drug Information

Drug General Information
Drug ID
D08VGJ
Former ID
DNC008145
Drug Name
5,6-dichloro-3,4-dihydroquinazolin-2-amine
Drug Type
Small molecular drug
Indication Discovery agent Investigative [529148]
Structure
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2D MOL

3D MOL
Formula
C8H7Cl2N3
Canonical SMILES
C1C2=C(C=CC(=C2Cl)Cl)NC(=N1)N
InChI
1S/C8H7Cl2N3/c9-5-1-2-6-4(7(5)10)3-12-8(11)13-6/h1-2H,3H2,(H3,11,12,13)
InChIKey
VBKOTIVQMCTTAQ-UHFFFAOYSA-N
PubChem Compound ID
9904281
Target and Pathway
Target(s) 5-hydroxytryptamine 1D receptor Target Info Inhibitor [529148]
5-hydroxytryptamine 7 receptor Target Info Inhibitor [529148]
5-hydroxytryptamine receptor 3A Target Info Inhibitor [529148]
5-hydroxytryptamine 6 receptor Target Info Inhibitor [529148]
5-hydroxytryptamine 2A receptor Target Info Inhibitor [529148]
5-hydroxytryptamine 1A receptor Target Info Inhibitor [529148]
5-hydroxytryptamine 2C receptor Target Info Inhibitor [529148]
5-hydroxytryptamine 5A receptor Target Info Inhibitor [529148]
KEGG Pathway cAMP signaling pathway
Neuroactive ligand-receptor interaction
Serotonergic synapsehsa04014:Ras signaling pathway
Calcium signaling pathway
Serotonergic synapsehsa04726:Serotonergic synapsehsa04020:Calcium signaling pathway
Serotonergic synapsehsa04020:Calcium signaling pathway
Gap junction
Serotonergic synapse
Inflammatory mediator regulation of TRP channelshsa04024:cAMP signaling pathway
Inflammatory mediator regulation of TRP channelshsa04020:Calcium signaling pathway
NetPath Pathway IL2 Signaling Pathway
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
5HT1 type receptor mediated signaling pathwayP00026:Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathwayP04375:5HT3 type receptor mediated signaling pathwayP00026:Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathwayP04374:5HT2 type receptor mediated signaling pathwayP00026:Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
5HT1 type receptor mediated signaling pathwayP04374:5HT2 type receptor mediated signaling pathwayP00026:Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
PathWhiz Pathway Excitatory Neural Signalling Through 5-HTR 7 and SerotoninPW000444:Excitatory Neural Signalling Through 5-HTR 6 and Serotonin
Reactome Serotonin receptors
G alpha (i) signalling eventsR-HSA-390666:Serotonin receptors
G alpha (s) signalling eventsR-HSA-975298:Ligand-gated ion channel transportR-HSA-390666:Serotonin receptors
G alpha (s) signalling eventsR-HSA-390666:Serotonin receptors
G alpha (q) signalling eventsR-HSA-390666:Serotonin receptors
G alpha (i) signalling events
WikiPathways Serotonin HTR1 Group and FOS Pathway
Monoamine GPCRs
GPCRs, Class A Rhodopsin-like
GPCR ligand binding
GPCR downstream signalingWP734:Serotonin Receptor 4/6/7 and NR3C Signaling
GPCR downstream signaling
GPCRs, OtherWP706:SIDS Susceptibility Pathways
Iron uptake and transportWP734:Serotonin Receptor 4/6/7 and NR3C Signaling
GPCR downstream signalingWP733:Serotonin Receptor 2 and STAT3 Signaling
Serotonin Receptor 2 and ELK-SRF/GATA4 signaling
SIDS Susceptibility Pathways
Gastrin-CREB signalling pathway via PKC and MAPK
GPCRs, OtherWP722:Serotonin HTR1 Group and FOS Pathway
GPCR downstream signalingWP732:Serotonin Receptor 2 and ELK-SRF/GATA4 signaling
GPCR downstream signalingWP58:Monoamine GPCRs
References
Ref 529148Bioorg Med Chem Lett. 2008 Jan 1;18(1):256-61. Epub 2007 Oct 30.Cyclic guanidines as dual 5-HT5A/5-HT7 receptor ligands: structure-activity relationship elucidation.
Ref 529148Bioorg Med Chem Lett. 2008 Jan 1;18(1):256-61. Epub 2007 Oct 30.Cyclic guanidines as dual 5-HT5A/5-HT7 receptor ligands: structure-activity relationship elucidation.

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