Drug General Information
Drug ID	D08VJI
Former ID	DIB005673
Drug Name	F-14413
Synonyms	Alpha-2 adrenoceptor antagonist (Alzheimer's disease), Pierre Fabre
Indication	Alzheimer disease [ICD9: 331; ICD10:G30]		Terminated	[547865]
Company	Pierre Fabre SA
Structure		Download 2D MOL 3D MOL
Canonical SMILES	N1CCN=C1[C@@]1(Oc2c(OC1)c(ccc2)F)OC.Cl
Target and Pathway
Target(s)	Alpha-2C adrenergic receptor	Target Info	Antagonist	[527640]
KEGG Pathway	cGMP-PKG signaling pathway
	Neuroactive ligand-receptor interaction
PANTHER Pathway	Alpha adrenergic receptor signaling pathway
	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
Reactome	Adrenoceptors
	Adrenaline signalling through Alpha-2 adrenergic receptor
	Adrenaline,noradrenaline inhibits insulin secretion
	G alpha (i) signalling events
	G alpha (z) signalling events
	Surfactant metabolism
WikiPathways	Monoamine GPCRs
	GPCRs, Class A Rhodopsin-like
	Platelet Aggregation (Plug Formation)
	Integration of energy metabolism
	GPCR ligand binding
	GPCR downstream signaling
References
Ref 547865	Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800019997)
Ref 527640	Activation of noradrenergic transmission by alpha2-adrenoceptor antagonists counteracts deafferentation-induced neuronal death and cell proliferation in the adult mouse olfactory bulb. Exp Neurol. 2005 Aug;194(2):444-56.

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