Drug General Information
Drug ID	D08WQJ
Former ID	DNC007634
Drug Name	(3-nitro-1H-pyrazol-1-yl)(phenyl)methanone
Drug Type	Small molecular drug
Indication	Discovery agent		Investigative	[529037]
Structure		Download 2D MOL 3D MOL
Formula	C10H7N3O3
Canonical SMILES	C1=CC=C(C=C1)C(=O)N2C=CC(=N2)[N+](=O)[O-]
InChI	1S/C10H7N3O3/c14-10(8-4-2-1-3-5-8)12-7-6-9(11-12)13(15)16/h1-7H
InChIKey	MIWUBRDWBKJULS-UHFFFAOYSA-N
PubChem Compound ID	700133
Target and Pathway
Target(s)	Leukocyte elastase	Target Info	Inhibitor	[529037]
	Plasma kallikrein	Target Info	Inhibitor	[529037]
	Coagulation factor IIa	Target Info	Inhibitor	[529037]
KEGG Pathway	Transcriptional misregulation in cancer
	Systemic lupus erythematosushsa04610:Complement and coagulation cascadeshsa04080:Neuroactive ligand-receptor interaction
	Complement and coagulation cascades
	Regulation of actin cytoskeleton
NetPath Pathway	AndrogenReceptor Signaling PathwayNetPath_11:TCR Signaling Pathway
PANTHER Pathway	Blood coagulationP00011:Blood coagulation
Pathway Interaction Database	Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling
	C-MYB transcription factor networkthrombin_pathway:Thrombin/protease-activated receptor (PAR) pathway
	Angiopoietin receptor Tie2-mediated signaling
	FOXA2 and FOXA3 transcription factor networks
	PAR4-mediated thrombin signaling events
	Syndecan-4-mediated signaling events
	PAR1-mediated thrombin signaling events
PathWhiz Pathway	CoagulationPW000047:Vitamin K Metabolism
	Coagulation
Reactome	Collagen degradation
	Degradation of the extracellular matrix
	Activation of Matrix MetalloproteinasesR-HSA-140837:Intrinsic Pathway of Fibrin Clot Formation
	Common Pathway of Fibrin Clot Formation
	Gamma-carboxylation of protein precursors
	Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus
	Removal of aminoterminal propeptides from gamma-carboxylated proteins
	Cell surface interactions at the vascular wall
	Peptide ligand-binding receptors
	Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
	G alpha (q) signalling events
	Thrombin signalling through proteinase activated receptors (PARs)
WikiPathways	Hair Follicle Development: Cytodifferentiation (Part 3 of 3)
	Human Complement System
	Degradation of collagenWP558:Complement and Coagulation Cascades
	Blood Clotting Cascade
	Formation of Fibrin Clot (Clotting Cascade)WP558:Complement and Coagulation Cascades
	Regulation of Actin Cytoskeleton
	IL1 and megakaryotyces in obesity
	Regulation of Insulin-like Growth Factor (IGF) Transport and Uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
	PTM: gamma carboxylation, hypusine formation and arylsulfatase activation
	Gastrin-CREB signalling pathway via PKC and MAPK
	Thrombin signalling through proteinase activated receptors (PARs)
	Platelet Aggregation (Plug Formation)
	GPCR ligand binding
	GPCR downstream signaling
	Formation of Fibrin Clot (Clotting Cascade)
	Cell surface interactions at the vascular wall
	Folate Metabolism
	Vitamin B12 Metabolism
	Selenium Micronutrient Network
References
Ref 529037	J Med Chem. 2007 Oct 4;50(20):4928-38. Epub 2007 Sep 12.N-benzoylpyrazoles are novel small-molecule inhibitors of human neutrophil elastase.
Ref 529037	J Med Chem. 2007 Oct 4;50(20):4928-38. Epub 2007 Sep 12.N-benzoylpyrazoles are novel small-molecule inhibitors of human neutrophil elastase.

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