Drug General Information
Drug ID	D08ZRA
Former ID	DNC012758
Drug Name	C-Naphthalen-1-yl-methylamine
Drug Type	Small molecular drug
Indication	Discovery agent		Investigative	[534531]
Structure		Download 2D MOL 3D MOL
Formula	C11H11N
Canonical SMILES	C1=CC=C2C(=C1)C=CC=C2CN
InChI	1S/C11H11N/c12-8-10-6-3-5-9-4-1-2-7-11(9)10/h1-7H,8,12H2
InChIKey	NVSYANRBXPURRQ-UHFFFAOYSA-N
PubChem Compound ID	8355
Target and Pathway
Target(s)	Alpha-2A adrenergic receptor	Target Info	Inhibitor	[534531]
	Alpha-2B adrenergic receptor	Target Info	Inhibitor	[534531]
	Alpha-2C adrenergic receptor	Target Info	Inhibitor	[534531]
KEGG Pathway	cGMP-PKG signaling pathway
	Neuroactive ligand-receptor interactionhsa04022:cGMP-PKG signaling pathway
	Neuroactive ligand-receptor interaction
PANTHER Pathway	Alpha adrenergic receptor signaling pathwayP00002:Alpha adrenergic receptor signaling pathway
	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathwayP00002:Alpha adrenergic receptor signaling pathway
	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
Reactome	Adrenoceptors
	Adrenaline signalling through Alpha-2 adrenergic receptor
	Adrenaline,noradrenaline inhibits insulin secretion
	G alpha (i) signalling events
	G alpha (z) signalling events
	Surfactant metabolismR-HSA-390696:Adrenoceptors
	G alpha (z) signalling eventsR-HSA-390696:Adrenoceptors
	Surfactant metabolism
WikiPathways	Monoamine GPCRs
	GPCRs, Class A Rhodopsin-like
	Platelet Aggregation (Plug Formation)
	Integration of energy metabolism
	GPCR ligand binding
	GPCR downstream signalingWP58:Monoamine GPCRs
	GPCR downstream signaling
References
Ref 534531	J Med Chem. 1997 Dec 5;40(25):3997-4005.Examination of the role of the acidic hydrogen in imparting selectivity of 7-(aminosulfonyl)-1,2,3,4-tetrahydroisoquinoline (SK&F 29661) toward inhibition of phenylethanolamine N-methyltransferase vs the alpha 2-adrenoceptor.
Ref 534531	J Med Chem. 1997 Dec 5;40(25):3997-4005.Examination of the role of the acidic hydrogen in imparting selectivity of 7-(aminosulfonyl)-1,2,3,4-tetrahydroisoquinoline (SK&F 29661) toward inhibition of phenylethanolamine N-methyltransferase vs the alpha 2-adrenoceptor.

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