Drug General Information
Drug ID	D0939G
Drug Name	Quisinostat
Indication	Advanced stage follicular lymphoma [ICD9: 202; ICD10:C82]		Phase 2	[1725891]
Structure		Download 2D MOL 3D MOL
Target and Pathway
Target(s)	Histone deacetylase 4	Target Info	Inhibitor	[1725887]
KEGG Pathway	Alcoholism
	Epstein-Barr virus infection
	Viral carcinogenesis
	MicroRNAs in cancer
NetPath Pathway	IL2 Signaling Pathway
Pathway Interaction Database	Signaling events mediated by HDAC Class II
	Signaling events mediated by HDAC Class III
	Signaling events mediated by HDAC Class I
	Sumoylation by RanBP2 regulates transcriptional repression
	Validated nuclear estrogen receptor alpha network
Reactome	NOTCH1 Intracellular Domain Regulates Transcription
	Constitutive Signaling by NOTCH1 PEST Domain Mutants
	Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
WikiPathways	Endochondral Ossification
	Cardiac Hypertrophic Response
	Neural Crest Differentiation
	miR-targeted genes in muscle cell - TarBase
	miR-targeted genes in lymphocytes - TarBase
	miR-targeted genes in epithelium - TarBase
	TarBasePathway
	Cell Cycle
	MicroRNAs in cardiomyocyte hypertrophy
References
Ref 1725891	ClinicalTrials.gov (NCT01486277) A Study of the Histone Deacetylase Inhibitor (HDACi) Quisinostat (JNJ-26481585) in Patients With Previously Treated Stage Ib-IVa Cutaneous T-cell Lymphoma
Ref 1725887	Wikipedia: Quisinostat

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