Drug General Information
Drug ID	D09ALE
Former ID	DIB004159
Drug Name	Enadoline
Synonyms	Enadoline hydrochloride; PD-129290
Drug Type	Small molecular drug
Indication	Pain [ICD9: 338, 356.0, 356.8,780; ICD10:G64, G90.0, R52, G89]		Phase 2	[525469], [539017]
Company	Parke-Davis & Co
Structure		Download 2D MOL 3D MOL
Formula	C24H32N2O3
InChIKey	JMBYBVLCYODBJQ-HFMPRLQTSA-N
PubChem Compound ID	60768
PubChem Substance ID	7978937, 8187043, 14756836, 14854504, 43118116, 50074386, 50261659, 103316363, 104132519, 104321590, 117567760, 124954353, 128294778, 135047989, 135650230, 137249416, 142304409, 144210744, 163414464, 163849334, 172873091, 178100466, 179149737, 189053426, 198935044, 223541403, 226573299, 252484391
Target and Pathway
Target(s)	Kappa-type opioid receptor	Target Info	Agonist	[525469]
KEGG Pathway	Neuroactive ligand-receptor interaction
PANTHER Pathway	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
	Opioid prodynorphin pathway
Reactome	Peptide ligand-binding receptors
	G alpha (i) signalling events
WikiPathways	GPCRs, Class A Rhodopsin-like
	Peptide GPCRs
	GPCR ligand binding
	GPCR downstream signaling
References
Ref 525469	Enadoline, a selective kappa-opioid receptor agonist shows potent antihyperalgesic and antiallodynic actions in a rat model of surgical pain. Pain. 1999 Mar;80(1-2):383-9.
Ref 539017	(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 1646).
Ref 525469	Enadoline, a selective kappa-opioid receptor agonist shows potent antihyperalgesic and antiallodynic actions in a rat model of surgical pain. Pain. 1999 Mar;80(1-2):383-9.

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