Drug General Information
Drug ID	D09BHA
Former ID	DIB009485
Drug Name	LY-353433
Synonyms	LY-343031; LY-343032; LY-314580 (oxalate); LY-350355 (maleate)
Indication	Inflammatory bowel disease [ICD9: 555, 556; ICD10:K50, K51]		Terminated	[546330]
Company	Eli Lilly & Co Ltd
Structure		Download 2D MOL 3D MOL
Canonical SMILES	c1(nn(c2c1cccc2)C(C)C)C(=O)NCCN1CCC(NC(=O)C23CC4CC(C3)C<br />C(C2)C4)CC1
Target and Pathway
Target(s)	5-hydroxytryptamine 4 receptor	Target Info	Antagonist	[534112]
KEGG Pathway	Calcium signaling pathway
	cAMP signaling pathway
	Neuroactive ligand-receptor interaction
	Serotonergic synapse
PANTHER Pathway	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
	5HT4 type receptor mediated signaling pathway
PathWhiz Pathway	Excitatory Neural Signalling Through 5-HTR 4 and Serotonin
Reactome	Serotonin receptors
	G alpha (s) signalling events
WikiPathways	Serotonin Receptor 4/6/7 and NR3C Signaling
	Monoamine GPCRs
	GPCRs, Class A Rhodopsin-like
	GPCR ligand binding
	GPCR downstream signaling
References
Ref 546330	Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800007508)
Ref 534112	LY353433, a potent, orally effective, long-acting 5-HT(4) receptor antagonist: comparison to cisapride and RS23597-190. J Pharmacol Exp Ther. 1996 Apr;277(1):97-104.

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