Drug General Information
Drug ID
D09BYB
Former ID
DNC010178
Drug Name
2-(tert-butylamino)-1-p-tolylpropan-1-one
Drug Type
Small molecular drug
Indication Discovery agent Investigative [530728]
Structure
Download
2D MOL

3D MOL

Formula
C14H21NO
Canonical SMILES
CC1=CC=C(C=C1)C(=O)C(C)NC(C)(C)C
InChI
1S/C14H21NO/c1-10-6-8-12(9-7-10)13(16)11(2)15-14(3,4)5/h6-9,11,15H,1-5H3
InChIKey
BMWDQBTXNBGORC-UHFFFAOYSA-N
PubChem Compound ID
Target and Pathway
Target(s) Sodium-dependent noradrenaline transporter Target Info Inhibitor [530728]
Sodium-dependent dopamine transporter Target Info Inhibitor [530728]
KEGG Pathway Dopaminergic synapse
Parkinson's disease
Cocaine addiction
Amphetamine addiction
Alcoholism
PANTHER Pathway Adrenaline and noradrenaline biosynthesisP00001:Adrenaline and noradrenaline biosynthesis
Parkinson disease
Dopamine receptor mediated signaling pathway
Pathway Interaction Database Alpha-synuclein signaling
Reactome Na+/Cl- dependent neurotransmitter transportersR-HSA-442660:Na+/Cl- dependent neurotransmitter transporters
WikiPathways Monoamine Transport
NRF2 pathway
Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compoundsWP727:Monoamine Transport
Dopaminergic Neurogenesis
Parkinsons Disease Pathway
Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds
Neurotransmitter Clearance In The Synaptic Cleft
References
Ref 530728J Med Chem. 2010 Mar 11;53(5):2204-14.Synthesis and biological evaluation of bupropion analogues as potential pharmacotherapies for smoking cessation.
Ref 530728J Med Chem. 2010 Mar 11;53(5):2204-14.Synthesis and biological evaluation of bupropion analogues as potential pharmacotherapies for smoking cessation.

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