Drug Information

Drug General Information
Drug ID
D09CKI
Former ID
DNC003964
Drug Name
CORYNANTHEINE
Drug Type
Small molecular drug
Indication Discovery agent Investigative [527393]
Structure
Download
2D MOL

3D MOL
Formula
C22H26N2O3
Canonical SMILES
COC=C(C1CC2C3=C(CCN2CC1C=C)C4=CC=CC=C4N3)C(=O)OC
InChI
1S/C22H26N2O3/c1-4-14-12-24-10-9-16-15-7-5-6-8-19(15)23-21(16)20(24)11-17(14)18(13-26-2)22(25)27-3/h4-8,13-14,17,20,23H,1,9-12H2,2-3H3/b18-13-/t14-,17-,20-/m0/s1
InChIKey
TZUGIFAYWNNSAO-CPHCKLLXSA-N
PubChem Compound ID
3000320
Target and Pathway
Target(s) Alpha-1D adrenergic receptor Target Info Inhibitor [533638]
Alpha-1A adrenergic receptor Target Info Inhibitor [527393]
Voltage-dependent L-type calcium channel subunit alpha-1C Target Info Inhibitor [533638]
Alpha-1B adrenergic receptor Target Info Inhibitor [533638]
KEGG Pathway Calcium signaling pathway
cGMP-PKG signaling pathway
Neuroactive ligand-receptor interaction
Adrenergic signaling in cardiomyocytes
Vascular smooth muscle contraction
Salivary secretionhsa04020:Calcium signaling pathway
AMPK signaling pathway
Salivary secretionhsa04010:MAPK signaling pathway
cAMP signaling pathway
Cardiac muscle contraction
Circadian entrainment
Long-term potentiation
Retrograde endocannabinoid signaling
Glutamatergic synapse
Cholinergic synapse
Serotonergic synapse
GABAergic synapse
Dopaminergic synapse
Insulin secretion
GnRH signaling pathway
Oxytocin signaling pathway
Type II diabetes mellitus
Alzheimer's disease
Amphetamine addiction
Hypertrophic cardiomyopathy (HCM)
Arrhythmogenic right ventricular cardiomyopathy (ARVC)
Dilated cardiomyopathyhsa04020:Calcium signaling pathway
Salivary secretion
NetPath Pathway IL2 Signaling PathwayNetPath_14:IL2 Signaling PathwayNetPath_14:IL2 Signaling Pathway
PANTHER Pathway Alpha adrenergic receptor signaling pathwayP00003:Alzheimer disease-amyloid secretase pathway
Nicotinic acetylcholine receptor signaling pathway
5HT2 type receptor mediated signaling pathway
Beta1 adrenergic receptor signaling pathway
Beta2 adrenergic receptor signaling pathway
Oxytocin receptor mediated signaling pathway
Nicotine pharmacodynamics pathwayP00002:Alpha adrenergic receptor signaling pathway
Pathway Interaction Database LPA receptor mediated events
PathWhiz Pathway Muscle/Heart Contraction
Reactome Adrenoceptors
G alpha (q) signalling events
G alpha (12/13) signalling eventsR-HSA-390696:Adrenoceptors
G alpha (12/13) signalling eventsR-HSA-400042:Adrenaline,noradrenaline inhibits insulin secretion
NCAM1 interactions
Regulation of insulin secretionR-HSA-390696:Adrenoceptors
G alpha (12/13) signalling events
WikiPathways Monoamine GPCRs
Calcium Regulation in the Cardiac Cell
GPCRs, Class A Rhodopsin-like
Gastrin-CREB signalling pathway via PKC and MAPK
GPCR ligand binding
GPCR downstream signaling
GPCRs, OtherWP58:Monoamine GPCRs
Endothelin Pathways
AMPK SignalingWP536:Calcium Regulation in the Cardiac Cell
Arrhythmogenic Right Ventricular Cardiomyopathy
Alzheimers Disease
NCAM signaling for neurite out-growth
Integration of energy metabolism
Nicotine Activity on Chromaffin CellsWP58:Monoamine GPCRs
Vitamin D Receptor Pathway
AMPK Signaling
References
Ref 527393Bioorg Med Chem Lett. 2005 Feb 1;15(3):657-64.Pharmacophore identification of alpha(1A)-adrenoceptor antagonists.
Ref 527393Bioorg Med Chem Lett. 2005 Feb 1;15(3):657-64.Pharmacophore identification of alpha(1A)-adrenoceptor antagonists.
Ref 533638J Med Chem. 1995 Sep 15;38(19):3681-716.Alpha- and beta-adrenoceptors: from the gene to the clinic. 2. Structure-activity relationships and therapeutic applications.

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