Drug Information

Drug General Information
Drug ID
D09DWL
Former ID
DAP000266
Drug Name
Zaleplon
Synonyms
Sonata; Zalaplon; Zerene; CL 284846; L 846; L846; LJC 10846; ZAL 846; AZ-007; CL 284,846; CL-284846; CL284,846; L-846; LJC-10846; SKP-1041; Sonata (TN); Staccato-zaleplon; Starnoc (TN); ZAL-846; Zaleplon [USAN:INN]; Zaleplon (JAN/USAN/INN); N-[3-(3-cyanopyrazolo[1,5-a]pyrimidin-7-yl)phenyl]-N-ethylacetamide; N-(3-(3-Cyanopyrazolo(1,5-a)pyrimidin-7-yl)phenyl)-N-ethylacetamide; 3'-(3-Cyanopyrazolo(1,5-a)pyrimidin-7-yl)-N-ethylacetanilide; 3'-(3-Cyanopyrazolo(1,5-alpha)pyrimidin-7-yl)-N-ethylacetanilide
Drug Type
Small molecular drug
Indication Insomnia [ICD9: 307.41, 307.42, 327.0, 780.51, 780.52; ICD10:F51.0, G47.0] Approved [467682], [538325]
Therapeutic Class
Hypnotics and Sedatives
Company
King Pharm
Structure
Download
2D MOL

3D MOL
Formula
C17H15N5O
InChI
InChI=1S/C17H15N5O/c1-3-21(12(2)23)15-6-4-5-13(9-15)16-7-8-19-17-14(10-18)11-20-22(16)17/h4-9,11H,3H2,1-2H3
InChIKey
HUNXMJYCHXQEGX-UHFFFAOYSA-N
CAS Number
CAS 151319-34-5
PubChem Compound ID
5719
PubChem Substance ID
9687, 5366116, 7847596, 8153504, 12014056, 14751928, 26719706, 29216208, 29224756, 46386657, 46508267, 48416707, 49831110, 49858710, 50064487, 57288874, 57322911, 58107163, 76325725, 81041179, 81093138, 87246409, 92308631, 92714203, 93166204, 103558703, 104179081, 104310058, 104829286, 124360324, 124659160, 125341659, 126629628, 126655581, 126669582, 128115429, 131299907, 134337580, 135017416, 135698186, 135710033, 136352570, 136897476, 137001621, 142240621, 144089038, 144205425, 160964301, 162011443, 162022385
SuperDrug ATC ID
N05CF03
SuperDrug CAS ID
cas=151319345
Target and Pathway
Target(s) Gamma-aminobutyric acid receptor subunit alpha-1 Target Info Modulator [556264]
KEGG Pathway Neuroactive ligand-receptor interaction
Retrograde endocannabinoid signaling
GABAergic synapse
Morphine addiction
Nicotine addiction
Reactome Ligand-gated ion channel transport
GABA A receptor activation
WikiPathways SIDS Susceptibility Pathways
Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell
Iron uptake and transport
References
Ref 467682(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 4345).
Ref 538325FDA Approved Drug Products from FDA Official Website. 2009. Application Number: (ANDA) 077237.
Ref 556264Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services.

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