Drug General Information
Drug ID	D09FQB
Former ID	DIB003894
Drug Name	UR-12460
Indication	Thromboembolism [ICD9: 437.6, 453, 671.5, 671.9; ICD10:I80-I82]		Terminated	[545849]
Company	Grupo Uriach
Structure		Download 2D MOL 3D MOL
Canonical SMILES	N1(C(=O)CNC(c2ccccc2)c2ccccc2)CCN(C(c2c(nccc2)C)C#N)CC1
CAS Number	CAS 149691-90-7
Target and Pathway
Target(s)	Platelet-activating factor receptor	Target Info	Modulator	[533626]
KEGG Pathway	Calcium signaling pathway
	Neuroactive ligand-receptor interaction
	Staphylococcus aureus infection
NetPath Pathway	IL5 Signaling Pathway
	Leptin Signaling Pathway
Reactome	Class A/1 (Rhodopsin-like receptors)
	G alpha (q) signalling events
	Interferon gamma signaling
WikiPathways	GPCRs, Class A Rhodopsin-like
	Gastrin-CREB signalling pathway via PKC and MAPK
	Small Ligand GPCRs
	Interferon gamma signaling
	GPCR ligand binding
	GPCR downstream signaling
References
Ref 545849	Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800005037)
Ref 533626	Platelet-activating factor: the effector of protein-rich plasma extravasation and nitric oxide synthase induction in rat immune complex peritonitis. Br J Pharmacol. 1995 Feb;114(4):895-901.

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