Drug Information

Drug General Information
Drug ID
D09FQT
Former ID
DIB018687
Drug Name
7alpha-N3-ginkgolide B
Drug Type
Small molecular drug
Indication Discovery agent Investigative [539151]
Structure
Download
2D MOL
Formula
C20H23N3O10
InChI
InChI=1S/C20H23N3O10/c1-5-12(26)30-11-8(24)18-10-6(22-23-21)7(16(2,3)4)17(18)9(25)13(27)32-15(17)33-20(18,14(28)31-10)19(5,11)29/h5-11,15,24-25,29H,1-4H3/q-1/t5?,6-,7?,8?,9-,10?,11-,15?,17?,18?,19+,20-/m0/s1
InChIKey
QHUUTLYBXWTSBQ-AQPRMESZSA-N
PubChem Compound ID
73755016
PubChem Substance ID
135652659
Target and Pathway
Target(s) Platelet-activating factor receptor Target Info Antagonist [526536]
KEGG Pathway Calcium signaling pathway
Neuroactive ligand-receptor interaction
Staphylococcus aureus infection
NetPath Pathway IL5 Signaling Pathway
Leptin Signaling Pathway
Reactome Class A/1 (Rhodopsin-like receptors)
G alpha (q) signalling events
Interferon gamma signaling
WikiPathways GPCRs, Class A Rhodopsin-like
Gastrin-CREB signalling pathway via PKC and MAPK
Small Ligand GPCRs
Interferon gamma signaling
GPCR ligand binding
GPCR downstream signaling
References
Ref 539151(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 1842).
Ref 526536Preparation of 7-substituted ginkgolide derivatives: potent platelet activating factor (PAF) receptor antagonists. J Med Chem. 2003 Feb 13;46(4):601-8.

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