Drug Information

Drug General Information
Drug ID
D09GXF
Former ID
DIB014416
Drug Name
RB-105
Synonyms
S-21402; S-21402-1; N-[2(S)-(Mercaptomethyl)-3(R)-phenylbutyl]-L-alanine
Drug Type
Small molecular drug
Indication Hypertension [ICD9: 401; ICD10:I10-I16] Investigative [1560271], [1560277], [1560322]
Structure
Download
2D MOL

3D MOL
Formula
C14H19NO3S
Canonical SMILES
CC(C1=CC=CC=C1)C(CS)C(=O)NC(C)C(=O)O
InChI
1S/C14H19NO3S/c1-9(11-6-4-3-5-7-11)12(8-19)13(16)15-10(2)14(17)18/h3-7,9-10,12,19H,8H2,1-2H3,(H,15,16)(H,17,18)/t9-,10-,12-/m0/s1
InChIKey
ABBSOQIXYPZCKO-NHCYSSNCSA-N
CAS Number
CAS 155895-89-9
PubChem Compound ID
5487537
PubChem Substance ID
14848765, 17185470, 39473187, 57364307, 77183962, 113995239, 135087848, 135818653
Target and Pathway
Target(s) Neutral endopeptidase Target Info Modulator
Angiotensin-converting enzyme Target Info Modulator
KEGG Pathway Renin-angiotensin system
Hematopoietic cell lineage
Protein digestion and absorption
Alzheimer's diseasehsa04614:Renin-angiotensin system
Chagas disease (American trypanosomiasis)
Hypertrophic cardiomyopathy (HCM)
NetPath Pathway EGFR1 Signaling Pathway
TGF_beta_Receptor Signaling Pathway
PathWhiz Pathway Angiotensin Metabolism
Reactome Metabolism of Angiotensinogen to AngiotensinsR-HSA-2022377:Metabolism of Angiotensinogen to Angiotensins
WikiPathways Metabolism of Angiotensinogen to Angiotensins
Primary Focal Segmental Glomerulosclerosis FSGS
Alzheimers DiseaseWP554:ACE Inhibitor Pathway
References
Ref 1560271Reversal of cardiac hypertrophy and fibrosis by S21402, a dual inhibitor of neutral endopeptidase and angiotensin converting enzyme in SHRs.
Ref 1560277Beneficial renal and cardiac effects of vasopeptidase inhibition with S21402 in heart failure.
Ref 1560322Renal and vascular effects of S21402, a dual inhibitor of angiotensin-converting enzyme and neutral endopeptidase, in healthy subjects with hypovolemia.

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