Drug Information

Drug General Information
Drug ID
D09GYT
Former ID
DAP000796
Drug Name
Methoxamine
Synonyms
Methoxamedrin; Methoxamedrine; Methoxamin; Methoxaminum; Metossamina; Metoxamina; Pseudomethoxamine; Vasoxin; Vasoxine; Metossamina [DCIT]; Methoxamine (BAN); Methoxamine [INN:BAN]; Methoxaminum [INN-Latin]; Metoxamina [INN-Spanish]; AQ-387/40213491; Alpha-(1-Aminoethyl)-2,5-dimethoxybenzyl alcohol; DL-2-Amino-1-(2,5-dimethoxyphenyl)propanol; 2-Amino-1-(2,5-dimethoxyphenyl)-1-propanol; 2-Amino-1-(2,5-dimethoxyphenyl)propanol; 2-amino-1-(2,5-dimethoxyphenyl)propan-1-ol; 2-amino-1-[2,5-bis(methyloxy)phenyl]propan-1-ol
Drug Type
Small molecular drug
Indication Hypertension [ICD9: 401; ICD10:I10-I16] Approved [468062], [550776]
Therapeutic Class
Antihypertensive Agents
Company
Glaxosmithkline
Structure
Download
2D MOL

3D MOL
Formula
C11H17NO3
InChI
InChI=1S/C11H17NO3/c1-7(12)11(13)9-6-8(14-2)4-5-10(9)15-3/h4-7,11,13H,12H2,1-3H3
InChIKey
WJAJPNHVVFWKKL-UHFFFAOYSA-N
CAS Number
CAS 390-28-3
PubChem Compound ID
6082
PubChem Substance ID
9716, 3249415, 7640130, 8153800, 10521352, 11363915, 11366477, 11369039, 11371595, 11373680, 11377201, 11466563, 11467683, 11484588, 11486206, 11488592, 11490314, 11491866, 11494835, 14822464, 29225091, 46506264, 47275534, 47275535, 47424221, 47943743, 48018885, 48094523, 48243341, 48416249, 49698962, 49892579, 50105260, 50941559, 53790926, 57323173, 85209476, 90341132, 95511867, 96024891, 103174599, 103936361, 104311067, 124749985, 124880762, 124880763, 125823506, 126688480, 129588714, 134338081
SuperDrug ATC ID
C01CA10
SuperDrug CAS ID
cas=000390283
Target and Pathway
Target(s) Alpha-1B adrenergic receptor Target Info Stimulator [537237]
KEGG Pathway Calcium signaling pathway
cGMP-PKG signaling pathway
Neuroactive ligand-receptor interaction
Adrenergic signaling in cardiomyocytes
Vascular smooth muscle contraction
Salivary secretion
NetPath Pathway IL2 Signaling Pathway
PANTHER Pathway Alpha adrenergic receptor signaling pathway
Pathway Interaction Database LPA receptor mediated events
Reactome Adrenoceptors
G alpha (q) signalling events
G alpha (12/13) signalling events
WikiPathways Monoamine GPCRs
Calcium Regulation in the Cardiac Cell
GPCRs, Class A Rhodopsin-like
Vitamin D Receptor Pathway
Gastrin-CREB signalling pathway via PKC and MAPK
GPCR ligand binding
GPCR downstream signaling
AMPK Signaling
References
Ref 468062(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 483).
Ref 550776Drug information of Methoxamine, 2008. eduDrugs.
Ref 537237Activation of alpha1-adrenoceptors Inhibits Growth Hormone Secretion in Humans. Exp Clin Endocrinol Diabetes. 2009 Apr 16.

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