Drug Information

Drug General Information
Drug ID
D09HJL
Former ID
DIB018795
Drug Name
AL-37350A
Synonyms
AL37350A; AL 37350A
Drug Type
Small molecular drug
Indication Discovery agent Investigative [538978]
Structure
Download
2D MOL
Formula
C14H18N2O
InChI
InChI=1S/C14H18N2O/c1-9(15)7-10-8-16-12-4-5-13-11(14(10)12)3-2-6-17-13/h4-5,8-9,16H,2-3,6-7,15H2,1H3/t9-/m0/s1
InChIKey
VVHJUSGIUWQPIT-VIFPVBQESA-N
PubChem Compound ID
10331436
PubChem Substance ID
15341684, 22698518, 33964502, 47359941, 48254007, 80617450, 103369094, 104024144, 135649913, 137187472, 162220015, 231710286
Target and Pathway
Target(s) 5-hydroxytryptamine 2C receptor Target Info Agonist [526713]
5-hydroxytryptamine 2B receptor Target Info Agonist [526713]
5-hydroxytryptamine 2A receptor Target Info Agonist [526713]
KEGG Pathway Calcium signaling pathway
Neuroactive ligand-receptor interaction
Gap junction
Serotonergic synapse
Inflammatory mediator regulation of TRP channelshsa04020:Calcium signaling pathway
Inflammatory mediator regulation of TRP channels
PANTHER Pathway 5HT2 type receptor mediated signaling pathwayP04374:5HT2 type receptor mediated signaling pathwayP04374:5HT2 type receptor mediated signaling pathway
Reactome Serotonin receptors
G alpha (q) signalling eventsR-HSA-390666:Serotonin receptors
G alpha (q) signalling events
WikiPathways Serotonin Receptor 2 and ELK-SRF/GATA4 signaling
Monoamine GPCRs
GPCRs, Class A Rhodopsin-like
Gastrin-CREB signalling pathway via PKC and MAPK
GPCR ligand binding
GPCR downstream signalingWP732:Serotonin Receptor 2 and ELK-SRF/GATA4 signaling
GPCR downstream signalingWP733:Serotonin Receptor 2 and STAT3 Signaling
SIDS Susceptibility Pathways
GPCR downstream signaling
GPCRs, Other
References
Ref 538978(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 160).
Ref 526713J Med Chem. 2003 Sep 11;46(19):4188-95.A novel and selective 5-HT2 receptor agonist with ocular hypotensive activity: (S)-(+)-1-(2-aminopropyl)-8,9-dihydropyrano[3,2-e]indole.

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