Drug Information

Drug General Information
Drug ID
D09HJS
Former ID
DIB003547
Drug Name
BIZELESIN
Synonyms
Bizelesin < Rec INN; U-77779; (S,S)-1,3-Bis[2-[1-(Chloromethyl)-5-hydroxy-8-methyl-1,2,3,6-tetrahydrobenzo[1,2-b:4,3-b']dipyrrol-3-ylcarbonyl]-1H-indol-5-yl]urea
Drug Type
Small molecular drug
Indication Skin disease [ICD10:L00-L99] Phase 1 [521448]
Structure
Download
2D MOL

3D MOL
Formula
C43H36Cl2N8O5
Canonical SMILES
Cc1c[nH]c2c(O)cc3N(C[C@@H](CCl)c3c12)C(=O)c4cc5cc(NC(=O<br />)Nc6ccc7[nH]c(cc7c6)C(=O)N8C[C@@H](CCl)c9c8cc(O)c%10[nH<br />]cc(C)c9%10)ccc5[nH]4
InChI
1S/C43H36Cl2N8O5/c1-19-15-46-39-33(54)11-31-37(35(19)39)23(13-44)17-52(31)41(56)29-9-21-7-25(3-5-27(21)50-29)48-43(58)49-26-4-6-28-22(8-26)10-30(51-28)42(57)53-18-24(14-45)38-32(53)12-34(55)40-36(38)20(2)16-47-40/h3-12,15-16,23-24,46-47,50-51,54-55H,13-14,17-18H2,1-2H3,(H2,48,49,58)/t23-,24-/m1/s1
InChIKey
FONKWHRXTPJODV-DNQXCXABSA-N
CAS Number
CAS 129655-21-6
PubChem Compound ID
60794
Target and Pathway
Target(s) Human DNA Target Info Inhibitor [533918]
References
Ref 521448ClinicalTrials.gov (NCT00003021) Bizelesin in Treating Patients With Advanced Cancer. U.S. National Institutes of Health.
Ref 533918Mapping of DNA alkylation sites induced by adozelesin and bizelesin in human cells by ligation-mediated polymerase chain reaction. Biochemistry. 1994 May 17;33(19):6024-30.

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