Drug General Information
Drug ID	D09KUY
Former ID	DNC012792
Drug Name	4-Chloro-7-methyl-2-phenyl-[1,8]naphthyridine
Drug Type	Small molecular drug
Indication	Discovery agent		Investigative	[525857]
Structure		Download 2D MOL 3D MOL
Formula	C15H11ClN2
Canonical SMILES	CC1=NC2=C(C=C1)C(=CC(=N2)C3=CC=CC=C3)Cl
InChI	1S/C15H11ClN2/c1-10-7-8-12-13(16)9-14(18-15(12)17-10)11-5-3-2-4-6-11/h2-9H,1H3
InChIKey	CMSOCFLZPHQUAD-UHFFFAOYSA-N
PubChem Compound ID	12431921
Target and Pathway
Target(s)	Adenosine A1 receptor	Target Info	Inhibitor	[525857]
KEGG Pathway	cGMP-PKG signaling pathway
	cAMP signaling pathway
	Sphingolipid signaling pathway
	Neuroactive ligand-receptor interaction
	Morphine addiction
NetPath Pathway	TCR Signaling Pathway
	RANKL Signaling Pathway
PANTHER Pathway	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
Reactome	Adenosine P1 receptors
	G alpha (i) signalling events
WikiPathways	Nucleotide GPCRs
	GPCRs, Class A Rhodopsin-like
	GPCR ligand binding
	GPCR downstream signaling
References
Ref 525857	J Med Chem. 2000 Jul 27;43(15):2814-23.A novel class of highly potent and selective A1 adenosine antagonists: structure-affinity profile of a series of 1,8-naphthyridine derivatives.
Ref 525857	J Med Chem. 2000 Jul 27;43(15):2814-23.A novel class of highly potent and selective A1 adenosine antagonists: structure-affinity profile of a series of 1,8-naphthyridine derivatives.

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