Drug Information

Drug General Information
Drug ID
D09OAQ
Former ID
DNC001453
Drug Name
TNP-470
Drug Type
Small molecular drug
Indication Solid tumours [ICD9: 140-199, 210-229; ICD10:C00-D48] Discontinued in Phase 2 [544934]
Structure
Download
2D MOL

3D MOL
Formula
C19H28ClNO6
Canonical SMILES
CC(=CCC1C(O1)(C)C2C(C(CCC23CO3)OC(=O)NC(=O)CCl)OC)C
InChI
1S/C19H28ClNO6/c1-11(2)5-6-13-18(3,27-13)16-15(24-4)12(7-8-19(16)10-25-19)26-17(23)21-14(22)9-20/h5,12-13,15-16H,6-10H2,1-4H3,(H,21,22,23)/t12-,13+,15-,16-,18-,19+/m1/s1
InChIKey
MSHZHSPISPJWHW-HUTWWKRSSA-N
CAS Number
CAS 198904-31-3
PubChem Compound ID
14942883
PubChem Substance ID
49899057, 135016855, 140349401, 249178932
ChEBI ID
ChEBI:37924
Target and Pathway
Target(s) Methionine aminopeptidase 2 Target Info Inhibitor [535871]
Reactome Inactivation, recovery and regulation of the phototransduction cascade
References
Ref 544934Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800001587)
Ref 535871Tumor suppression by a rationally designed reversible inhibitor of methionine aminopeptidase-2. Cancer Res. 2003 Nov 15;63(22):7861-9.

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