Drug Information

Drug General Information
Drug ID
D09OKK
Former ID
DNC004217
Drug Name
LG-120838
Drug Type
Small molecular drug
Indication Discovery agent Investigative [534728]
Structure
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2D MOL

3D MOL
Formula
C27H25NO
Canonical SMILES
CC1=CC=CC=C1C=C2C3=C(C=CC4=C3C(=CC(N4)(C)C)C)C5=CC=CC=C<br />5O2
InChI
1S/C27H25NO/c1-17-9-5-6-10-19(17)15-24-26-21(20-11-7-8-12-23(20)29-24)13-14-22-25(26)18(2)16-27(3,4)28-22/h5-16,28H,1-4H3/b24-15-
InChIKey
YXKBVHXOKVRRKO-IWIPYMOSSA-N
PubChem Compound ID
9951771
Target and Pathway
Target(s) Mineralocorticoid receptor Target Info Inhibitor [534728]
mRNA of androgen receptor Target Info Inhibitor [534728]
mRNA of glucocorticoid receptor Target Info Inhibitor [534728]
KEGG Pathway Aldosterone-regulated sodium reabsorptionhsa04114:Oocyte meiosis
Pathways in cancer
Prostate cancerhsa04080:Neuroactive ligand-receptor interaction
NetPath Pathway EGFR1 Signaling Pathway
AndrogenReceptor Signaling Pathway
FSH Signaling PathwayNetPath_14:IL2 Signaling Pathway
TCR Signaling Pathway
Pathway Interaction Database Regulation of nuclear SMAD2/3 signaling
Coregulation of Androgen receptor activity
Regulation of Androgen receptor activity
Nongenotropic Androgen signaling
Regulation of nuclear beta catenin signaling and target gene transcription
FOXA1 transcription factor network
Notch-mediated HES/HEY networksmad2_3nuclearpathway:Regulation of nuclear SMAD2/3 signaling
Signaling events mediated by HDAC Class II
FOXA2 and FOXA3 transcription factor networks
Glucocorticoid receptor regulatory network
AP-1 transcription factor network
PathWhiz Pathway Kidney Function
Reactome Nuclear Receptor transcription pathway
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3R-HSA-1368108:BMAL1:CLOCK,NPAS2 activates circadian gene expression
WikiPathways ACE Inhibitor PathwayWP706:SIDS Susceptibility Pathways
Integrated Pancreatic Cancer Pathway
Prostate Cancer
Integrated Breast Cancer Pathway
Nuclear Receptors
Androgen receptor signaling pathwayWP734:Serotonin Receptor 4/6/7 and NR3C Signaling
SIDS Susceptibility Pathways
Endoderm Differentiation
Hair Follicle Development: Cytodifferentiation (Part 3 of 3)
Adipogenesis
Circadian Clock
References
Ref 534728J Med Chem. 1998 Oct 22;41(22):4354-9.5-Benzylidene 1,2-dihydrochromeno[3,4-f]quinolines, a novel class of nonsteroidal human progesterone receptor agonists.
Ref 534728J Med Chem. 1998 Oct 22;41(22):4354-9.5-Benzylidene 1,2-dihydrochromeno[3,4-f]quinolines, a novel class of nonsteroidal human progesterone receptor agonists.

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