Drug Information

Drug General Information
Drug ID
D09PIN
Former ID
DNC001283
Drug Name
SB 224289
Drug Type
Small molecular drug
Indication Discovery agent Investigative [538798]
Structure
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2D MOL

3D MOL
Formula
C32H32N4O3
InChI
InChI=1S/C32H32N4O3/c1-20-16-25(30-33-21(2)39-34-30)8-9-26(20)22-4-6-23(7-5-22)31(37)36-13-10-24-17-29-27(18-28(24)36)32(19-38-29)11-14-35(3)15-12-32/h4-9,16-18H,10-15,19H2,1-3H3
InChIKey
ATQMRMGXINTJHV-UHFFFAOYSA-N
CAS Number
CAS 180083-23-2
PubChem Compound ID
3378093
PubChem Substance ID
4494824, 7980569, 9939000, 11111767, 11113970, 14909661, 24263016, 36152438, 47721701, 50104768, 53786940, 57356229, 80253748, 85209284, 103187893, 103984445, 111968726, 124750292, 124881379, 124881380, 126167850, 127457698, 134340737, 135610879, 135650993, 136367794, 137275801, 160830076, 163094386, 163394393, 163843200, 164023449, 179150087, 204434045, 206245871, 223535495, 225058079, 233326276, 250212574, 251965677, 252070144, 252089569, 252433862
Target and Pathway
Target(s) 5-hydroxytryptamine 1B receptor Target Info Antagonist [534909]
KEGG Pathway cAMP signaling pathway
Neuroactive ligand-receptor interaction
Serotonergic synapse
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
5HT1 type receptor mediated signaling pathway
Reactome Serotonin receptors
G alpha (i) signalling events
WikiPathways Serotonin HTR1 Group and FOS Pathway
Monoamine GPCRs
GPCRs, Class A Rhodopsin-like
GPCR ligand binding
GPCR downstream signaling
References
Ref 538798(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 130).
Ref 5349095-hydroxytryptamine receptors mediating contraction in human small muscular pulmonary arteries: importance of the 5-HT1B receptor. Br J Pharmacol. 1999 Oct;128(3):730-4.

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