Drug General Information
Drug ID	D09QRL
Former ID	DNC012238
Drug Name	2-Methyl-8-phenyl-1,2,3,4-tetrahydro-isoquinoline
Drug Type	Small molecular drug
Indication	Discovery agent		Investigative	[533578]
Structure		Download 2D MOL 3D MOL
Formula	C16H17N
Canonical SMILES	CN1CCC2=CC=CC(=C2C1)C3=CC=CC=C3
InChI	1S/C16H17N/c1-17-11-10-14-8-5-9-15(16(14)12-17)13-6-3-2-4-7-13/h2-9H,10-12H2,1H3
InChIKey	XBKQADUXVZAYDY-UHFFFAOYSA-N
PubChem Compound ID	3057770
Target and Pathway
Target(s)	Dopamine D1 receptor	Target Info	Inhibitor	[533578]
	D(2) dopamine receptor	Target Info	Inhibitor	[533578]
KEGG Pathway	Calcium signaling pathway
	cAMP signaling pathway
	Neuroactive ligand-receptor interaction
	Gap junction
	Dopaminergic synapse
	Parkinson's disease
	Cocaine addiction
	Amphetamine addiction
	Morphine addiction
	Alcoholismhsa04015:Rap1 signaling pathway
	Alcoholism
PANTHER Pathway	Dopamine receptor mediated signaling pathwayP00026:Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
	Dopamine receptor mediated signaling pathway
	Nicotine pharmacodynamics pathway
PathWhiz Pathway	Dopamine Activation of Neurological Reward System
Reactome	Dopamine receptors
	G alpha (s) signalling eventsR-HSA-390651:Dopamine receptors
	G alpha (i) signalling events
WikiPathways	Hypothetical Network for Drug Addiction
	Monoamine GPCRs
	GPCRs, Class A Rhodopsin-like
	Genes and (Common) Pathways Underlying Drug Addiction
	GPCR ligand binding
	GPCR downstream signalingWP666:Hypothetical Network for Drug Addiction
	GPCR downstream signaling
	Nicotine Activity on Dopaminergic Neurons
References
Ref 533578	J Med Chem. 1981 Sep;24(9):1107-10.Synthesis and evaluation of 1,2,3,4-tetrahydro[1]benzothieno[2,3-h]isoquinolines as dopamine antagonists.
Ref 533578	J Med Chem. 1981 Sep;24(9):1107-10.Synthesis and evaluation of 1,2,3,4-tetrahydro[1]benzothieno[2,3-h]isoquinolines as dopamine antagonists.

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