Drug Information

Drug General Information
Drug ID
D09QZI
Former ID
DAP001210
Drug Name
Norgestimate
Synonyms
Norgestimato; Norgestimatum; Dexnorgestrel acetime; Norgestrel oxime acetate; D 138; ORF 10131; RWJ 10131; Norgestimato [INN-Spanish]; Norgestimatum [INN-Latin]; ORF-10131; Ortho-Prefest; RWJ-10131; Norgestimate (USP/INN); Norgestimate [USAN:INN:BAN]; D-13beta-Ethyl-17alpha-ethynyl-17beta-acetoxygon-4-en-3-oneoxime; D-13-beta-Ethyl-17-alpha-ethynyl-17-beta-acetoxygon-4-en-3-one oxime; [(3E,8R,9S,10R,13S,14S,17R)-13-ethyl-17-ethynyl-3-hydroxyimino-1,2,6,7,8,9,10,11,12,14,15,16-dodecahydrocyclopenta[a]phenanthren-17-yl] acetate; (+)-13-Ethyl-17-hydroxy-18,19-dinor-17alpha-pregn-4-en-20-yn-3-one oxime acetate (ester); (17-alpha)-17-(Acetyloxy)-13-ethyl-18,19-dinorpregn-4-en-20-yn-3-one 3-oxime; (17alpha)-17-(Acetyloxy)-13-ethyl-18,19-dinorpregn-4-en-20-yn-3-one 3-oxime; (3E)-17alpha-ethynyl-3-(hydroxyimino)-18a-homoestr-4-en-17beta-yl acetate
Drug Type
Small molecular drug
Indication Hormonal contraceptives [ICD10:Z30] Approved [536361], [542097]
Therapeutic Class
Contraceptive Agents
Structure
Download
2D MOL

3D MOL
Formula
C23H31NO3
InChI
InChI=1S/C23H31NO3/c1-4-22-12-10-19-18-9-7-17(24-26)14-16(18)6-8-20(19)21(22)11-13-23(22,5-2)27-15(3)25/h2,14,18-21,26H,4,6-13H2,1,3H3/b24-17+/t18-,19+,20+,21-,22-,23-/m0/s1
InChIKey
KIQQMECNKUGGKA-NMYWJIRASA-N
CAS Number
CAS 35189-28-7
PubChem Compound ID
6540478
PubChem Substance ID
12013307, 14828760, 14877333, 23948292, 43185588, 46507381, 47206928, 49963131, 50125945, 50406385, 53787279, 56352967, 57370933, 92712530, 99375924, 103770917, 114617529, 126630090, 126656639, 126670754, 131311636, 134338450, 135000359, 135046943, 137002813, 141484503, 144206364, 152056974, 160964296, 162174921, 170464733, 175267643, 176250054, 179150362, 196110215, 223396532, 223556630, 223668437, 226423899, 226423900, 241064393, 249822572, 252062710, 252355235
ChEBI ID
ChEBI:50815
Target and Pathway
Target(s) Progesterone receptor Target Info Agonist [536305], [537309]
KEGG Pathway Oocyte meiosis
Progesterone-mediated oocyte maturation
Pathway Interaction Database Cellular roles of Anthrax toxin
Reactome Nuclear signaling by ERBB4
Nuclear Receptor transcription pathway
WikiPathways Ovarian Infertility Genes
Signaling by ERBB4
Nuclear Receptors
References
Ref 536361Natural products as sources of new drugs over the last 25 years. J Nat Prod. 2007 Mar;70(3):461-77. Epub 2007 Feb 20.
Ref 542097(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7091).
Ref 536305A review of transdermal hormonal contraception : focus on the ethinylestradiol/norelgestromin contraceptive patch. Treat Endocrinol. 2006;5(6):359-65.
Ref 537309Pharmacological profile of progestins. Maturitas. 2008 Sep-Oct;61(1-2):151-7.

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